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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
anna
Casey
anna.casey@uhb.nhs.uk
Dr
Miruna
David
miruna.david@uhb.nhs.uk
More information about this study, what is involved and how to take part can be found on the study website.
Other diseases of urinary system
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Complicated urinary tract infections (cUTI) are associated with significant morbidity and mortality. Due to the high frequency of UTI, they have a major impact on antibiotic use and the antibiotic resistance of prominent UTI bacteria is of recognised importance. Therefore, UTIs, and particularly cUTIs, are a target for repurposing of old and neglected drugs, new drug development and non-antibiotic therapeutic and preventive approaches.
The objectives of this multinational prospective observational cohort study are to:
• continuously evaluate best practices related to patient enrolment and data collection to improve study execution
• collect information to support the design of innovative clinical trials and population enrichment.
• determine the incidence of treatment failure in patients with cUTI
• determine modifiable and non-modifiable risk factors for treatment failure in patients with cUTI
• describe the patient population with cUTI and the microbiological causes of cUTI in the study sites
• determine the rate of recurrences and superinfections, and those caused by multidrug-resistant bacteria
• determine the mortality and its predictors in patients with cUTI
• determine the length of hospital stay after cUTI
• investigate outcomes (treatment failure and mortality) and outcome predictors in subgroup of patients, including elderly patients, patients with urinary catheters, patients with bacteria in their blood, intensive care patients, patients with hospital-acquired cUTI, patients with multidrug-resistant bacteria
• describe variations in current practices in treating cUTI in the study sites
The study will take place recruiting 16,000 patients in 40 sites across 10-20 European countries over a 4 year period. Any patient > = 18 years of age with a cUTI can be enrolled and studied for 30 days post-diagnosis.
Exclusions include patients who:
• are expected to survive for < 30 days or are exclusively for palliative care
• die < 48 hours after diagnosis
• are participating in an trial for treatment of cUTI
• were diagnosed with cUTI more than 96 hours previously.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
- Patients with a life expectancy previous to development of cUTI < 30 days and those exclusively under palliative care in whom any eventually needed invasive procedures would not be performed. - Patients who died in < 48 hours since the presentation with cUTI. - Patients participating in RCT for treatment of cUTI. - > 96 hours since the clinical diagnosis of cUTI.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Miruna
David
miruna.david@uhb.nhs.uk
Dr
anna
Casey
anna.casey@uhb.nhs.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by University Medical Centre Utrecht (Netherlands) and funded by European Commission .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 54461
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
