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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
John
McGrath
john.mcgrath@kcl.ac.uk
Prof
John
McGrath
john.mcgrath@kcl.ac.uk
Dermatitis and eczemaUrticaria and erythema
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Background
Cutaneous allergy refers to a broad range of skin conditions mediated by inappropriate immune responses which produce itchy, erythematous rashes with or without scaling. They are common conditions, with an estimated point prevalence of 0.1-0.5% for chronic spontaneous urticaria and a similar estimated prevalence for allergic contact dermatitis. These conditions have a detrimental effect on quality of life as patients must control symptoms by avoiding precipitating allergens or by using oral antihistamines and topical corticosteroids. Risk of these conditions may be related to genetic predisposition as studies report an increased frequency amongst first degree relatives of affected individuals. Furthermore, observed large differences in clinical severity may be related to underlying genetic determinants. It is therefore important that genetic determinants of cutaneous allergy are investigated and correlated with clinical phenotypes as findings may facilitate more personalized or novel treatments for patients in the future.
Methods
A UK-wide research network will be established in order to allow recruitment of individuals with conditions related to cutaneous allergy. Site researchers will identify, recruit and consent potential participants before undertaking a thorough clinical examination and classification of their disease. Clinical information directly relevant to participants' diagnosis will be collected from their hospital notes. Living participants may be requested to donate blood, saliva or skin samples. Further samples may be derived from the St. John's Institute of Dermatology Research Tissue bank. DNA will be extracted from the blood/skin samples. Blood and skin samples will also be analysed for biochemical and protein contents. Gene mutation analysis will be performed on the DNA samples and analysed for relationship to the clinical phenotype. All data collected will be anonymised, used for the purpose of this study only, and analysed by the coordinating site/Chief Investigator adhering to strict national standards of privacy, security and confidentiality.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Genetic epidemiology;
You can take part if:
You may not be able to take part if:
Patients will be excluded from the study if they meet any of the following criteria: • Any inclusion criteria not met • Adult patients that lack capacity to consent to take part in the study
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by King's College London and funded by NIHR Guy's and St Thomas' Biomedical Research Centre .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 43481
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