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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Ms
Marte
Theilmann Jensen
marte.jensen.18@ucl.ac.uk
Prof
Huw
Morris
h.morris@ucl.ac.uk
Riona
Fumi
riona.fumi@nhs.net
Riona
Fumi
riona.fumi@nhs.net
Ms
Marte
Theilmann Jensen
marte.jensen.18@ucl.ac.uk
Extrapyramidal and movement disorders
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Progressive Supranuclear Palsy, Corticobasal syndrome and Multiple System Atrophy are degenerative brain conditions. We need better methods of diagnosis and tracking disease progression. This can be improved by: a) detailed clinical study of patients with these diseases; b) study of change in patients’ clinical state over time; c)studying “biomarkers” such as blood or spinal fluid diagnosis or tracking the disease course; and d) including studying “biomarkers” such as blood or spinal fluid diagnosis or tracking the disease course; and d) including patients with very early disease who do not currently meet “definite” clinical criteria for disease in this group. Being involved in the study will involve: a) reading the project information sheet and completing a consent form; b) attending a research assessment on 5 occasions over 3 years; c) having a neurological assessment which will take 45 minutes; d) completing questionnaires; e) donating blood samples for research; f) agreeing that you can be contacted by phone or at a clinic appointment on two more occasions at 4 and 5 years. People unaffected by neurological disease will be asked to participate in the study on one occasion by completing questionnaires and assessments and donating blood samples. In some centres patients will be invited to have a lumbar puncture to examine the spinal fluid on three occasions and to have an MRI brain scan on two additional occasions. This will depend on local centres ability to offer these additional tests. We will also establish a UK-wide disease study, which will enable the participation of patients who able to travel to a study centre. Being involved with the UK- wide study will involve reviewing the patient information sheet, completing the consent form, completing a phone interview and returning study questionnaires. We will study improved methods of tracking and diagnosing these conditions. We hope that this will help in the development of new treatments.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Participant has another medical or psychiatric illness that would interfere in completing assessments. • Participant is pregnant. Lumbar puncture exclusion criteria • Anticoagulants such as warfarin. • Known coagulation abnormalities – known coagulopathy or platelet count <100 • Lumbar spinal surgery within 6 months prior to assessment, or any lumbar spinal surgery that interferes with anatomy of the inter-vertebral spaces. • History of chronic or repeat CSF leakage following previous lumbar puncture, or history of spontaneous or traumatic intracranial hypotension. • Active infectious process. MRI exclusion criteria • Usual local exclusion criteria apply
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
Huw
Morris
h.morris@ucl.ac.uk
Riona
Fumi
riona.fumi@nhs.net
Ms
Marte
Theilmann Jensen
marte.jensen.18@ucl.ac.uk
Riona
Fumi
riona.fumi@nhs.net
Ms
Marte
Theilmann Jensen
marte.jensen.18@ucl.ac.uk
The study is sponsored by University College London and funded by THE PSP ASSOCIATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 17302
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
