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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Ms
PLORAS
Research Team
ploras@ucl.ac.uk
Rachel
Bruce
ploras@ucl.ac.uk
Prof
Catherine
Price
c.j.price@ucl.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
Cerebrovascular diseasesSymptoms and signs involving speech and voice
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The aim of the study is to provide a clinical protocol that will Predict Language Outcome and Recovery After Stroke (PLORAS). The system we are developing takes a structural brain image of a new patient with language difficulties (aphasia) and produces probabilistic estimates of long term outcome, based on whether, when, and in what respects, other patients with “matching” lesions recovered their speech and language abilities.
The project rests on a database that records three types of information from many hundreds of stroke patients: language scores (from standardised assessment), structural MRI, and demographic information (age, time post stroke etc). Critical lesion sites for aphasic symptoms are identified by linking structural MRI and language scores. A combination of all data types then enters the PLORAS system, which predicts recovery from aphasia in new patients. In order to be successful, we need to study large numbers of patients who have had a stroke, some of whom have continuing problems with their language and some who don't. The information from this study will enable us to make predictions about likely recovery patterns in patients who suffer strokes in the future. This will help guide both clinical and experimental therapeutic interventions.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
Exclusion criteria (with associated justifications): Patients: • Significant medical or psychiatric comorbidity (unable to comply with: the behavioural assessments; or scanning (lying flat and remaining still) • Other neurological condition in addition to stroke e.g. dementia, MS, PD, MND (unable to be certain that symptoms/errors on assessment result from stroke rather than other condition). • Severe physical disability i.e. requiring hoist transfer (unable to access MRI scanner) • Over 24 stone (upper limit of MRI scanner table) • Pregnancy • Patients with contraindications to fMRI (pacemaker, noncompatible metallic implant, etc (see WTCN scanning checklist and SOP for other absolute and relative contraindications) • Less than 18 years old • Patient unable to provide informed consent and no family member/close friend to assent on their behalf
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Ms
PLORAS
Research Team
ploras@ucl.ac.uk
Rachel
Bruce
ploras@ucl.ac.uk
Prof
Catherine
Price
c.j.price@ucl.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by University College London and funded by Wellcome Trust .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 15511
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