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Contact Information:

Rasha Al-Lamee, PhD MRCP 020 7594 5735
r.al-lamee13@imperial.ac.uk


Fiyyaz Ahmed-Jushuf, MBBS MRCP 020 7594 5735
fiyyaz.ahmed-jushuf09@imperial.ac.uk


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Be Part of Research - Trial Details - Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina
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Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina

Recruiting

Open to: ALL

Age: 18.0 - N/A

London London London Bournemouth Portsmouth Basildon

Medical Conditions

Angina Pectoris
Angina, Stable

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


ORBITA-FIRE is a randomised, double-blinded, placebo controlled experimental study that will identify the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) thresholds that correlate with symptoms of angina for 58 patients measured invasively under experimental conditions.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2022 Apr 2025

OBSERVATIONAL

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : The degree of stenosis required to cause angina at rest will be measured under double-blinded placebo controlled conditions using sequential intracoronary balloon inflations. This will then be correlated with various physiological indices, including FFR and NHPR.

Intervention Arm Group : Patients with stable angina;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : The degree of stenosis required to cause angina during exercise will be measured under double-blinded placebo controlled conditions using sequential intracoronary balloon inflations. This will then be correlated with various physiological indices, including FFR and NHPR.

Intervention Arm Group : Patients with stable angina;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Free Hospital NHS Foundation Trust
    London
  • St George's University Hospitals NHS Foundation Trust
    London
  • Imperial College NHS Trust
    London
  • Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
    Bournemouth
  • Portsmouth Hospitals NHS Trust
    Portsmouth
  • Mid and South Essex NHS Foundation Trust
    Basildon

Rasha Al-Lamee, PhD MRCP 020 7594 5735
r.al-lamee13@imperial.ac.uk


Fiyyaz Ahmed-Jushuf, MBBS MRCP 020 7594 5735
fiyyaz.ahmed-jushuf09@imperial.ac.uk



The study is sponsored by Imperial College London and is in collaboration with Royal Free Hospital NHS Foundation Trust; Mid and South Essex NHS Foundation Trust; St George's University Hospitals NHS Foundation Trust; Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust; Portsmouth Hospitals NHS Trust.



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Read full details for Trial ID: NCT05459051
Last updated 04 March 2024

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