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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Pier Lambiase 07977217787
p.lambiase@ucl.ac.uk


CRAAFT-HF Team @ Barts CVCTU craaft-hf-cvctu@qmul.ac.uk


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Be Part of Research - Trial Details - Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart
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Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart

Recruiting

Open to: ALL

Age: 18.0 - N/A

Glasgow Birmingham London Leicester Leeds London London Portsmouth Cambridge London Plymouth Liverpool Coventry Blackpool Southampton Basildon Swansea Hull Nottingham Bournemouth London Middlesbrough Newcastle

Medical Conditions

Atrial Fibrillation (AF)

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Atrial fibrillation (AF) is a common heart rhythm disorder that causes an irregular heart beat and is a cause of heart failure (HF). Treatments include drugs to slow the heart rate, anti-arrhythmic drugs or ablation of the heart to help preserve normal rhythm. A number of trials have suggested that ablation may be superior to drug treatment to reduce hospitalisations or prevent early death. However, these studies have been small and the results not applicable to the general population with AF and heart failure in the UK. This international study will compare catheter ablation and optimal medical therapy versus optimal medical therapy alone to see if catheter ablation reduces unplanned heart failure hospitalisations and death rates and improves quality of life.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2024 Dec 2031

INTERVENTIONAL

Intervention Type : PROCEDURE
Intervention Description : Participants randomised to the catheter ablation arm will undergo Pulmonary Vein Isolation (PVI) which is the essential ablation intervention. The technique used will be at the discretion of the treating physician but may include Cryoballoon (Medtronic/Boston Scientific), Radiofrequency: CARTO (Biosense), pulsed field radiofrequency ablation, or Precision (Abbott Medical) electro-anatomical mapping systems. Additional ablation lesions may be delivered as preferred by the operator and will be documented. Electro-anatomical voltage maps will be collected (in SR/AF) and stored for later analysis.

Intervention Arm Group : The catheter ablation;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Golden Jubilee National Hospital
    Glasgow
    G81 4DY
  • Queen Elizabeth Hospital
    Birmingham
  • Barts Health NHS Trust
    London
  • Glenfield Hospital
    Leicester
  • Leeds Teaching Hospitals NHS Trust
    Leeds
  • Imperial College Healthcare NHS Trust
    London
  • St George's University Hospitals NHS Foundation Trust
    London
  • Queen Alexandra Hospital
    Portsmouth
  • Royal Papworth Hospital NHS Foundation Trust
    Cambridge
    CB2 0AY
  • St Thomas' Hospital
    London
  • University Hospitals Plymouth NHS Trust
    Plymouth
  • Liverpool Heart and Chest Hospital NHS Foundation Trust
    Liverpool
  • University Hospitals Coventry and Warwickshire NHS Trust
    Coventry
  • Blackpool Victoria Hospital
    Blackpool
  • Southampton General
    Southampton
  • Mid and South Essex NHS Foundation Trust
    Basildon
  • Swansea Bay University Health Board
    Swansea
  • Hull University Teaching Hospitals NHS Trust
    Hull
  • Nottingham University Hospital NHS Trust
    Nottingham
  • University Hospitals Dorset NHS Foundation Trust
    Bournemouth
  • Royal Brompton and Harefields Hospitals
    London
    UB9 6JH
  • James Cook University Hosptial
    Middlesbrough
  • Freeman Hospital, Royal Victoria Infirmary
    Newcastle

CRAAFT-HF Team @ Barts CVCTU craaft-hf-cvctu@qmul.ac.uk


Pier Lambiase 07977217787
p.lambiase@ucl.ac.uk



The study is sponsored by University College, London



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Read full details for Trial ID: NCT06505798
Last updated 28 April 2026

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