Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

Medical Conditions

Asthma


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically significant exacerbations in participants with severe asthma with an eosinophilic phenotype. Throughout the study, all participants will continue their non-biologic Baseline standard of care (SoC) asthma treatment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2021 Sep 2025

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : GSK3511294 (Depemokimab) will be provided in a single-use prefilled syringe (PFS).

Intervention Arm Group : Participants receiving GSK3511294 (Depemokimab) plus placebo matching prior anti-IL-5/5R treatment;

Intervention Type : BIOLOGICAL
Intervention Description : Mepolizumab will be provided in a single-use PFS.

Intervention Arm Group : Participants receiving prior anti-IL-5/5R treatment plus placebo matching GSK3511294 (Depemokimab);

Intervention Type : BIOLOGICAL
Intervention Description : Benralizumab will be provided in a single-use PFS.

Intervention Arm Group : Participants receiving prior anti-IL-5/5R treatment plus placebo matching GSK3511294 (Depemokimab);

Intervention Type : BIOLOGICAL
Intervention Description : Placebo will be a sterile liquid formulation.

Intervention Arm Group : Participants receiving GSK3511294 (Depemokimab) plus placebo matching prior anti-IL-5/5R treatment;Participants receiving prior anti-IL-5/5R treatment plus placebo matching GSK3511294 (Depemokimab);

Intervention Type : DRUG
Intervention Description : Non-biologic SoC will include inhaled corticosteroid (ICS) plus at least one other controller, long-acting beta-2-agonist (LABA), long-acting muscarinic antagonist (LAMA), with or without maintenance oral corticosteroids (OCS).

Intervention Arm Group : Participants receiving GSK3511294 (Depemokimab) plus placebo matching prior anti-IL-5/5R treatment;Participants receiving prior anti-IL-5/5R treatment plus placebo matching GSK3511294 (Depemokimab);

Intervention Type : DEVICE
Intervention Description : PFS will include glass barrel with pre-staked needle and plunger.

Intervention Arm Group : Participants receiving GSK3511294 (Depemokimab) plus placebo matching prior anti-IL-5/5R treatment;Participants receiving prior anti-IL-5/5R treatment plus placebo matching GSK3511294 (Depemokimab);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • GSK Investigational Site
    Liverpool
    L7 8XP
  • GSK Investigational Site
    Nottingham
    NG5 1PB
  • GSK Investigational Site
    Birmingham
    B9 5SS
  • GSK Investigational Site
    Glasgow
    G31 2ER
  • GSK Investigational Site
    Exeter
    EX2 5DW
  • GSK Investigational Site
    Wakefield
    WF1 4DG
  • GSK Investigational Site
    London
    EC1A 7BE
  • GSK Investigational Site
    Bradford
    BD9 6RJ
  • GSK Investigational Site
    Portsmouth
    PO6 3LY
  • GSK Investigational Site
    Oxford
    OX3 9DU
  • GSK Investigational Site
    Glasgow
    G51 4TF
  • GSK Investigational Site
    Belfast
    BT9 7AB
  • GSK Investigational Site
    Cottingham
    HU16 5JQ
  • GSK Investigational Site
    Preston
    PR2 9HT
  • GSK Investigational Site
    Bristol Avon
    BS10 5NB
  • GSK Investigational Site
    Newcastle Upon Tyne
    NE7 7DN
  • GSK Investigational Site
    Wishaw
    ML6 0JS


The study is sponsored by GlaxoSmithKline and is in collaboration with Iqvia Pty Ltd.




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT04718389
Last updated 10 March 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.