Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Amit Goyal, MS, MD, FRCS +44 1332785538
amit.goyal@nhs.net


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Medical Conditions

Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2021 Feb 2030

INTERVENTIONAL

Intervention Type : PROCEDURE
Intervention Description : Participants will undergo removal of at least level I and II axillary lymph nodes.

Intervention Arm Group : Axillary treatment;

Intervention Type : RADIATION
Intervention Description : Axillary radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.

Intervention Arm Group : Axillary treatment;

Intervention Type : RADIATION
Intervention Description : Breast or chest wall radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.

Intervention Arm Group : Axillary treatment;No axillary treatment;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Gateshead Health NHS Foundation Trust
    Gateshead
    NE9 6SX
  • Harrogate and District NHS Foundation Trust
    Harrogate
    HG2 7SX
  • Mid Yorkshire Hospitals NHS Trust
    Wakefield
    WF1 4DG
  • South Tees Hospitals NHS Foundation Trust
    Middlesbrough
    TS4 3BW
  • United Lincolnshire Hospitals NHS Trust
    Lincoln
    LN2 5QY
  • North Bristol NHS Trust
    Bristol
    BS10 5NB
  • University Hospitals of Leicester NHS Trust
    Leicester
    LE3 9QP
  • King's College Hospital NHS Foundation Trust
    London
    SE5 9RS
  • Lancashire Teaching Hospitals NHS Foundation Trust
    Preston
    PR2 9HT
  • Belfast Health and Social Care Trust
    Belfast
    BT9 7AB
  • Bradford Teaching Hospitals NHS Foundation Trust
    Bradford
    BD5 0NA
  • Royal Cornwall Hospitals NHS Trust
    Truro
    TR1 3LJ
  • North Middlesex University Hospital NHS Trust
    London
    N18 1QX
  • Hull University Teaching Hospitals NHS Trust
    Hull
    HU16 5JQ
  • Royal Devon and Exeter NHS Foundation Trust
    Exeter
    EX2 5DW
  • Northumbria Healthcare NHS Foundation Trust
    North Shields
    NE29 8NH
  • Nhs Lothian
    Edinburgh
    EH4 2XU
  • Bolton NHS Foundation Trust
    Bolton
    BL4 0JR
  • Frimley Health NHS Foundation Trust
    Camberley
    Gu16 7uj
  • The Rotherham NHS Foundation Trust
    Rotherham
    S60 2UD
  • University Hospitals of North Midlands NHS Trust
    Stoke-on-Trent
    ST4 6QG
  • The Dudley Group Nhs Foundation Trust
    Dudley
    DY1 2HQ
  • Newcastle upon Tyne Hospitals NHS Foundation Trust
    Newcastle upon Tyne
    NE1 4LP
  • Royal Berkshire NHS Foundation Trust
    Reading
    RG1 5AN
  • Hywel Dda University Health Board
    Llanelli
    SA14 8QF
  • County Durham and Darlington NHS Foundation Trust
    Darlington
    DL3 6HX
  • The Royal Marsden NHS Foundation Trust
    London
    SM2 5PT
  • University Hospitals Plymouth NHS Trust
    Plymouth
    PL6 8DH
  • James Paget University Hospitals Nhs Foundation Trust
    Great Yarmouth
    NR31 6LA
  • Airedale Nhs Foundation Trust
    Keighley
    BD20 6TD
  • Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
    Doncaster
    DN2 5LT
  • NHS Grampian
    Aberdeen
    AB25 2ZN
  • Oxford University Hospitals NHS Foundation Trust
    Oxford
    OX3 7LE
  • Imperial College Healthcare NHS Trust
    London
    W6 8RF
  • University Hospitals of Morecambe Bay NHS Foundation Trust
    Lancaster
    LA1 4RP
  • Croydon Health Services NHS Trust
    Thornton Heath
    CR7 7YE
  • North Tees and Hartlepool NHS Foundation Trust
    Stockton-on-Tees
    TS19 8PE
  • Swansea Bay University Health Board
    Swansea
    SA2 8QA
  • University Hospitals of Derby and Burton NHS Foundation Trust
    Derby
    DE22 3NE
  • East Lancashire Hospitals NHS Trust
    Burnley
    BB10 2PQ
  • Surrey & Sussex Healthcare NHS Trust
    Redhill
    RH1 5RH
  • East Suffolk and North Essex NHS Foundation Trust
    Ipswich
    IP4 5PD
  • Portsmouth Hospitals University NHS Trust
    Portsmouth
    PO6 3LY
  • Bedfordshire Hospitals NHS Foundation Trust
    Luton
    LU4 0DZ
  • Sandwell and West Birmingham NHS Trust
    Birmingham
    B18 7QH
  • Sheffield Teaching Hospitals NHS Foundation Trust
    Sheffield
    S10 2SJ
  • St Helens and Knowsley Teaching Hospitals NHS Trust
    Prescot
    L35 5DR
  • University Hospitals Sussex NHS Foundation Trust
    Brighton
    BN2 5BE
  • Clatterbridge Cancer Centre NHS Foundation Trust
    Wirral
    CH63 4JY
  • Calderdale and Huddersfield NHS Foundation Trust
    Huddersfield
    HD3 3EA
  • North Cumbria Integrated Care NHS Foundation Trust
    Carlisle
    Ca2 7hy
  • NHS Highland
    Inverness
    Iv2 3uj
  • East Cheshire NHS Trust
    Macclesfield
    Sk10 3bl.
  • The Shrewsbury and Telford Hospitals NHS Trust
    Shrewsbury
    Sy3 8xq
  • Ashford and St Peter's Hospitals NHS Foundation Trust
    Ashford
    TW15 3AA
  • Tameside and Glossop Integrated Care NHS Foundation Trust
    Ashton-under-Lyne
    OL6 9RW
  • NHS Ayrshire and Arran
    Ayr
    KA6 6DX
  • Countess of Chester Hospital NHS Trust
    Chester
    CH2 1HJ
  • Mid Cheshire NHS Foundation Trust
    Crewe
    CW1 4QJ
  • NHS Dumfries and Galloway
    Dumfries
    DG2 8RX
  • NHS Fife
    Dunfermline
    KY12 0SU
  • NHS Lanarkshire
    East Kilbride
    G75 8RG
  • Wye Valley NHS Trust
    Hereford
    HR1 2ER
  • Buckinghamshire Healthcare NHS Trust
    High Wycombe
    HP11 2TT
  • NHS Forth Valley
    Larbert
    FK5 4WR
  • Manchester University NHS Foundation Trust
    Manchester
    M8 5RB
  • NHS Borders
    Melrose
    TD6 9BS
  • Milton Keynes University Hospital NHS Trust
    Milton Keynes
    MK6 5LD
  • NHS Greater Glasgow and Clyde
    Paisley
    PA2 9PN
  • West Hertfordshire Hospitals NHS Trust
    St Albans
    AL3 5PN
  • Somerset NHS Foundation Trust
    Taunton
    TA1 5DA
  • Mid and South Essex NHS Foundation Trust
    Westcliff-on-Sea
    SS0 0RY
  • Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
    Wigan
    WN1 2NN
  • Wirral University Teaching Hospital NHS Foundation Trust
    Wirral
    CH63 4JY
  • Yeovil District Hospital NHS Trust
    Yeovil
    BA21 4AT
  • York and Scarborough Teaching Hospitals NHS Foundation Trust
    York
    YO31 8HE
  • Whittington Health NHS Trust
    London
    N19 5NF
  • Chelsea and Westminster Hospital NHS Foundation Trust
    Isleworth
    TW7 6AF
  • East and North Hertfordshire NHS Foundation Trust
    Stevenage
    SG1 4AB
  • University Hospitals Birmingham NHS Foundation Trust
    Birmingham
    B15 2GW
  • Cambridge University Hospitals NHS Foundation Trust
    Cambridge
    CB2 0QQ
  • Gloucestershire General Hospitals NHS Foundation Trust
    Cheltenham
    GL53 7AN
  • Leeds Teaching Hospitals NHS Trust
    Leeds
    LS9 7TF
  • University College London Hospitals NHS Foundation Trust
    London
    NW1 2BU
  • Royal Free London NHS Foundation Trust
    London
    NW3 2QG
  • The Royal Wolverhampton NHS Trust
    Wolverhampton
    WV10 0QP
  • Worcestershire Acute Hospitals NHS Trust
    Worcester
    WR5 1JR

Amit Goyal, MS, MD, FRCS +44 1332785538
amit.goyal@nhs.net



The study is sponsored by University Hospitals of Derby and Burton NHS Foundation Trust




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Read full details for Trial ID: NCT04109079
Last updated 22 October 2024

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