Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Amit Goyal, MS, MD, FRCS +44 1332785538
amit.goyal@nhs.net


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Medical Conditions

Breast Cancer
Sentinel Lymph Node
Neoplasm, Breast


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2021 Feb 2030

INTERVENTIONAL

Intervention Type : PROCEDURE
Intervention Description : Participants will undergo removal of at least level I and II axillary lymph nodes.

Intervention Arm Group : Axillary treatment;

Intervention Type : RADIATION
Intervention Description : Axillary radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.

Intervention Arm Group : Axillary treatment;

Intervention Type : RADIATION
Intervention Description : Breast or chest wall radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.

Intervention Arm Group : Axillary treatment;No axillary treatment;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Royal Marsden NHS Foundation Trust
    London
    SM2 5PT
  • Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board
    Glasgow
    G12 0YN
  • Royal Bolton Hospital - Bolton NHS Foundation Trust
    Bolton
    BL4 0JR
  • Southmead Hospital - North Bristol NHS Trust
    Bristol
    BS10 5NB
  • Darlington Memorial Hospital - County Durham and Darlington NHS Foundation Trust
    Darlington
    DL3 6HX
  • Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
    Cambridge
    CB2 0QQ
  • Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust
    Preston
    PR2 9HT
  • Churchill Hospital - Oxford University Hospitals NHS Foundation Trust
    Oxford
    OX3 7LE
  • Aberdeen Royal Infirmary - NHS Grampian
    Aberdeen
    AB25 2ZN
  • Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust
    Truro
    TR1 3LJ
  • St James's University Hospital - Leeds Teaching Hospitals NHS Trust
    Leeds
    LS9 7TF
  • Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust
    Stoke-on-Trent
    ST4 6QG
  • Harrogate District Hospital - Harrogate and District NHS Foundation Trust
    Harrogate
    HG2 7SX
  • Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust
    Brighton
    BN2 5BE
  • Airedale General Hospital - Airedale NHS Foundation Trust
    Keighley
    BD20 6TD
  • Cumberland Infirmary - North Cumbria Integrated Care NHS Foundation Trust
    Carlisle
    CA2 7HY
  • Frimley Park Hospital - Frimley Health NHS Foundation Trust
    Camberley
    GU16 7UJ
  • Raigmore Hospital - NHS Highland
    Inverness
    IV2 3UJ
  • James Paget Hospital -James Paget University Hospitals NHS Foundation Trust
    Great Yarmouth
    NR31 6LA
  • Royal Berkshire Hospital - Royal Berkshire NHS Foundation Trust
    Reading
    RG1 5AN
  • Macclesfield District General Hospital - East Cheshire NHS Trust
    Macclesfield
    SK10 3BL.
  • Royal Shrewsbury Hospital -The Shrewsbury and Telford Hospitals NHS Trust
    Shrewsbury
    SY3 8XQ
  • Ashford Hospital - Ashford and St Peter's Hospitals NHS Foundation Trust
    Ashford
    TW15 3AA
  • Tameside General Hospital- Tameside and Glossop Integrated Care NHS Foundation Trust
    Ashton-under-Lyne
    OL6 9RW
  • University Hospital Crosshouse - NHS Ayrshire and Arran
    Ayr
    KA6 6DX
  • Basildon University Hospital - Mid and South Essex NHS Foundation Trust
    Basildon
    SS16 5NL
  • Belfast City Hospital - Belfast Health and Social Care Trust
    Belfast
    BT9 7AB
  • QEHB- University Hospitals Birmingham NHS Foundation Trust
    Birmingham
    B15 2GW
  • City Hospital -Sandwell and West Birmingham NHS Trust
    Birmingham
    B18 7QH
  • Blackpool Victoria Hospital - Blackpool Teaching Hospitals NHS Foundation Trust
    Blackpool
  • St Luke's Hospital - Bradford Teaching Hospitals NHS Foundation Trust
    Bradford
    BD5 0NA
  • Burnley General Hospital- East Lancashire Hospitals NHS Trust
    Burnley
    BB10 2PQ
  • Cheltenham General Hospital - Gloucestershire General Hospitals NHS Foundation Trust
    Cheltenham
    GL53 7AN
  • Countess of Chester Hospital - Countess of Chester Hospital NHS Trust
    Chester
    CH2 1HJ
  • Leighton Hospital - Mid Cheshire NHS Foundation Trust
    Crewe
    CW1 4QJ
  • Royal Derby Hospital- University Hospitals of Derby and Burton NHS Foundation Trust
    Derby
    DE22 3NE
  • Doncaster Royal Infirmary - Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
    Doncaster
    DN2 5LT
  • Russell's Hall Hospital - The Dudley Group NHS Foundation Trust
    Dudley
    DY1 2HQ
  • Dumfries and Galloway Royal Infirmary - NHS Dumfries and Galloway
    Dumfries
    DG2 8RX
  • Queen Margert Hospital - NHS Fife
    Dunfermline
    KY12 0SU
  • University Hospital Hairmyres - NHS Lanarkshire
    East Kilbride
    G75 8RG
  • Western General Hospital -NHS Lothian
    Edinburgh
    EH4 2XU
  • Royal Devon & Exeter Hospital - Royal Devon and Exeter NHS Foundation Trust
    Exeter
    EX2 5DW
  • Queen Elizabeth Hospital - Gateshead Health NHS Foundation Trust
    Gateshead
    NE9 6SX
  • Royal Surrey County Hospital - Royal Surrey NHS Foundation Trust
    Guildford
    GU2 7XX
  • Hereford County Hospital- Wye Valley NHS Trust
    Hereford
    HR1 2ER
  • Wycombe Hospital - Buckinghamshire Healthcare NHS Trust
    High Wycombe
    HP11 2TT
  • Huddersfield Royal Infirmary- Calderdale and Huddersfield NHS Foundation Trust
    Huddersfield
    HD3 3EA
  • Castle Hill Hospital - Hull University Teaching Hospitals NHS Trust
    Hull
    HU16 5JQ
  • Ipswich Hospital - East Suffolk and North Essex NHS Foundation Trust
    Ipswich
    IP4 5PD
  • West Middlesex University Hospital - Chelsea and Westminster Hospital NHS Foundation Trust
    Isleworth
    TW7 6AF
  • Royal Lancaster Infirmary - University Hospitals of Morecambe Bay NHS Foundation Trust
    Lancaster
    LA1 4RP
  • Forth Valley Royal Hospital - NHS Forth Valley
    Larbert
    FK5 4WR
  • Glenfield Hospital - University Hospitals of Leicester NHS Trust
    Leicester
    LE3 9QP
  • Lincoln County Hospital - United Lincolnshire Hospitals NHS Trust
    Lincoln
    LN2 5QY
  • Prince Phillip Hospital -Hywel Dda University Health Board
    Llanelli
    SA14 8QF
  • North Middlesex University Hospital - North Middlesex University Hospital NHS Trust
    London
    N18 1QX
  • The Whittington Hospital - Whittington Health NHS Trust
    London
    N19 5NF
  • UCL Hospital - University College London Hospitals NHS Foundation Trust
    London
    NW1 2BU
  • Royal Free Hospital - Royal Free London NHS Foundation Trust
    London
    NW3 2QG
  • Kings College Hospital - King's College Hospital NHS Foundation Trust
    London
    SE5 9RS
  • Charing Cross Hospital -Imperial College Healthcare NHS Trust
    London
    W6 8RF
  • Luton and Dunstable Hospital -Bedfordshire Hospitals NHS Foundation Trust
    Luton
    LU4 0DZ
  • Wythenshawe Hospital - Manchester University Hospital NHS Foundation Trust
    Manchester
    M23 9LT
  • North Manchester General -Manchester University NHS Foundation Trust
    Manchester
    M8 5RB
  • Borders General Hospital -NHS Borders
    Melrose
    TD6 9BS
  • Clatterbridge Cancer Centre - The Clatterbridge Cancer Centre NHS Foundation Trust
    Metropolitan Borough of Wirral
    CH63 4JY
  • Clatterbridge Hospital - Wirral University Teaching Hospital NHS Foundation Trust
    Metropolitan Borough of Wirral
    CH63 4JY
  • The James Cook University Hospital - South Tees Hospitals NHS Foundation Trust
    Middlesbrough
    TS4 3BW
  • Milton Keynes Hospital - Milton Keynes University Hospital NHS Trust
    Milton Keynes
    MK6 5LD
  • Royal Victoria Infirmary- Newcastle Upon Tyne Hospitals NHS Foundation Trust
    Newcastle upon Tyne
    NE1 4LP
  • North Tyneside General Hospital - Northumbria Healthcare NHS Foundation Trust
    North Shields
    NE29 8NH
  • Royal Alexandra Hospital - NHS Greater Glasgow and Clyde
    Paisley
    PA2 9PN
  • Derriford Hospital - University Hospitals Plymouth NHS Trust
    Plymouth
    PL6 8DH
  • Queen Alexandra Hospital - Portsmouth Hospitals University NHS Trust
    Portsmouth
    PO6 3LY
  • St Helen's Hospital - St Helens and Knowsley Teaching Hospitals NHS Trust
    Prescot
    L35 5DR
  • East Surrey Hospital - Surrey & Sussex Healthcare NHS Trust
    Redhill
    RH1 5RH
  • Rotherham General Hospital - The Rotherham NHS Foundation Trust
    Rotherham
    S60 2UD
  • Weston Park Hospital - Sheffield Teaching Hospitals NHS Foundation Trust
    Sheffield
    S10 2SJ
  • St Alban's Hospital - West Hertfordshire Hospitals NHS Trust
    St Albans
    AL3 5PN
  • Lister Hospital - East and North Hertfordshire NHS Foundation Trust
    Stevenage
    SG1 4AB
  • University Hospital North Tees - North Tees and Hartlepool NHS Foundation Trust
    Stockton-on-Tees
    TS19 8PE
  • Singleton hospital - Swansea Bay University Health Board
    Swansea
    SA2 8QA
  • Musgrove park Hospital -Somerset NHS Foundation Trust
    Taunton
    TA1 5DA
  • Croydon University Hospital - Croydon Health Services NHS Trust
    Thornton Heath
    CR7 7YE
  • Hillingdon Hospital - The Hillingdon Hospitals NHS Foundation Trust
    Uxbridge
    UB8 3NN
  • Pinderfields Hospital - Mid Yorkshire Hospitals NHS Trust
    Wakefield
    WF1 4DG
  • Southend Hospital and Broomfield Hospital -Mid and South Essex NHS Foundation Trust
    Westcliff-on-Sea
    SS0 0RY
  • Royal Albert Edward Infirmary - Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
    Wigan
    WN1 2NN
  • King Edward VII Hospital - Frimley Health NHS Foundation Trust
    Windsor
    SL4 3DP
  • New Cross Hospital - The Royal Wolverhampton NHS Trust
    Wolverhampton
    WV10 0QP
  • Worcestershire Royal Hospital - Worcestershire Acute Hospitals NHS Trust
    Worcester
    WR5 1JR
  • Yeovil District Hospital -Yeovil District Hospital NHS Trust
    Yeovil
    BA21 4AT
  • York Hospital - York and Scarborough Teaching Hospitals NHS Foundation Trust
    York
    YO31 8HE

Amit Goyal, MS, MD, FRCS +44 1332785538
amit.goyal@nhs.net



The study is sponsored by University Hospitals of Derby and Burton NHS Foundation Trust





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Read full details for Trial ID: NCT04109079
Last updated 18 December 2025

This page is to help you find out about a research study and if you may be able to take part

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