Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Ann Henry
-
A.Henry@leeds.ac.uk


Dr Samantha Noutch
-
pointerpc@leeds.ac.uk


Study Location:

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Be Part of Research - Trial Details - A comparison of pelvic extended nodal irradiation and stereotactic body radiotherapy for patients with recurrent prostate cancer

A comparison of pelvic extended nodal irradiation and stereotactic body radiotherapy for patients with recurrent prostate cancer

Medical Conditions

Prostate cancer


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Prostate cancer can come back after previous treatment with surgery or radiotherapy in glands (known as lymph nodes) in the pelvis, which is what happened to you. When this happens, there are different treatments that could be used for your cancer, but we do not know for certain which treatment is best. The POINTER-PC study is trying to work this out.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Dec 2024 30 Nov 2028

Publications

2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/39725427/ (added 17/01/2025)

Two different types of radiotherapy could be used. The gland(s) could be treated with focused radiotherapy given in a small number of treatments (5 treatments), which is called stereotactic body radiotherapy (SBRT). Or, both the surrounding pelvis as well as the gland(s) known to be cancerous could be treated with radiotherapy. This is known as pelvis radiotherapy.


All participants approached about this study have prostate cancer which has come back in lymph glands in their pelvis.

You can take part if:



You may not be able to take part if:


1. Previous pelvic nodal radiotherapy2. Contraindications to SBRT or ENI (e.g. inflammatory bowel disease)3. Contraindications to ADT4. Local recurrence in the prostate gland5. Para-aortic nodal metastases (above the aortic bifurcation)6. Meso-rectal nodal metastases7. Bone or visceral metastases8. Severe late toxicity relating to primary/post-operative RT9. Other active malignancy (except non-melanoma skin cancer or other malignancy with a documented disease-free survival for a minimum of 3 years before randomisation)10. Castrate-resistant disease


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • South Tees Hospitals NHS Foundation Trust
    James Cook University Hospital Marton Road
    Middlesbrough
    TS4 3BW
  • NHS Lothian
    Waverley Gate 2-4 Waterloo Place
    Edinburgh
    EH1 3EG
  • Sheffield Teaching Hospitals NHS Foundation Trust
    Northern General Hospital Herries Road
    Sheffield
    S5 7AU
  • Torbay and South Devon NHS Foundation Trust
    Torbay Hospital Newton Road
    Torquay
    TQ2 7AA
  • Cambridge University Hospitals NHS Foundation Trust
    Cambridge Biomedical Campus Hills Road
    Cambridge
    CB2 0QQ
  • The Christie NHS Foundation Trust
    550 Wilmslow Road Withington
    Manchester
    M20 4BX
  • University College London Hospitals NHS Foundation Trust
    250 Euston Road
    London
    NW1 2PG
  • University Hospitals Birmingham NHS Foundation Trust
    Queen Elizabeth Hospital Mindelsohn Way Edgbaston
    Birmingham
    B15 2GW
  • Belfast Health and Social Care Trust
    Trust Headquarters A Floor - Belfast City Hospital Lisburn Road
    Belfast
    BT9 7AB
  • Leeds Teaching Hospitals NHS Trust
    St. James's University Hospital Beckett Street
    Leeds
    LS9 7TF
  • The Royal Marsden NHS Foundation Trust
    Fulham Road
    London
    SW3 6JJ
  • The Clatterbridge Cancer Centre NHS Foundation Trust
    Clatterbridge Hospital Clatterbridge Road Bebington
    Wirral
    CH63 4JY
  • Norfolk and Norwich University Hospitals NHS Foundation Trust
    Colney Lane Colney
    Norwich
    NR4 7UY
  • University Hospitals Bristol and Weston NHS Foundation Trust
    Trust Headquarters Marlborough Street
    Bristol
    BS1 3NU
  • Royal Free London NHS Foundation Trust
    Royal Free Hospital Pond Street
    London
    NW3 2QG
  • Royal Cornwall Hospitals NHS Trust
    Royal Cornwall Hospital Treliske
    Truro
    TR1 3LJ
  • The Newcastle upon Tyne Hospitals NHS Foundation Trust
    Freeman Hospital Freeman Road High Heaton
    Newcastle upon Tyne
    NE7 7DN
  • Imperial College Healthcare NHS Trust
    The Bays St Marys Hospital South Wharf Road
    London
    W2 1BL
  • Barts Health NHS Trust
    The Royal London Hospital 80 Newark Street
    London
    E1 2ES
  • University Hospitals of Derby and Burton NHS Foundation Trust
    Royal Derby Hospital Uttoxeter Road
    Derby
    DE22 3NE
  • United Lincolnshire Hospitals NHS Trust
    Lincoln County Hospital Greetwell Road
    Lincoln
    LN2 5QY
  • NORTH MIDDLESEX UNIVERSITY HOSPITAL NHS TRUST
    NORTH MIDDLESEX HOSPITAL STERLING WAY
    LONDON
    N18 1QX
  • Maidstone and Tunbridge Wells NHS Trust
    The Maidstone Hospital Hermitage Lane
    Maidstone
    ME16 9QQ
  • Hull University Teaching Hospitals NHS Trust
    Hull Royal Infirmary Anlaby Road
    Hull
    HU3 2JZ
  • Royal Surrey County Hospital NHS Foundation Trust
    Egerton Road
    Guildford
    GU2 7XX
  • Lancashire Teaching Hospitals NHS Foundation Trust
    Royal Preston Hospital Sharoe Green Lane Fulwood
    Preston
    PR2 9HT
  • Mid and South Essex NHS Foundation Trust
    Prittlewell Chase
    Westcliff-on-sea
    SS0 0RY
  • York and Scarborough Teaching Hospitals NHS Foundation Trust
    York Hospital Wigginton Road
    York
    YO31 8HE
  • Somerset NHS Foundation Trust
    Trust Management Lydeard House Musgrove Park Hospital
    Taunton
    TA1 5DA
  • East and North Hertfordshire NHS Trust
    Lister Hospital Coreys Mill Lane
    Stevenage
    SG1 4AB
  • Guys and St Thomas' NHS Foundation Trust
    249 Westminster Bridge Road
    London
    SE1 7EH
  • East Suffolk and North Essex NHS Foundation Trust
    Colchester Dist General Hospital Turner Road
    Colchester
    CO4 5JL
  • Greater Glasgow and Clyde
    Gartnavel Royal Hospital 1055 Great Western Road
    Glasgow
    G12 0XH

This study will compare pelvis radiotherapy with SBRT to see which is better at stopping the cancer from coming back again. Pelvis radiotherapy is usually given in 20 treatments, but it could be shortened to give it in 5 treatments instead. In the study, we will also check if pelvis radiotherapy can be safely given in 5 treatments instead of 20 treatments. Pelvis radiotherapy might be better than SBRT at stopping the cancer coming back again in the pelvis or in another part of the body. SBRT and pelvis radiotherapy in either 5 or 20 treatments can have side effects. Hormone therapies and chemotherapy also carry a risk of side effects.

Dr Ann Henry
-
A.Henry@leeds.ac.uk


Dr Samantha Noutch
-
pointerpc@leeds.ac.uk



The study is sponsored by University of Leeds and funded by Cancer Research UK; Yorkshire Cancer Research.





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Read full details for Trial ID: ISRCTN11089334

Or CPMS 62335

Last updated 17 January 2025

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