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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Mark
Edwards
-
admin@floela.org
Ms
Zoe
Clark
+44 (0)23 8120 1863
zoe.clark@uhs.nhs.uk
More information about this study, what is involved and how to take part can be found on the study website.
Surgery - emergency laparotomy
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Emergency bowel surgery (laparotomy) is a major procedure which can lead to reduced blood flow to vital organs. This can lead to complications after surgery. Fluids are given into the bloodstream (intravenous) to improve blood flow. Giving the right amount of this intravenous fluid at the right time is important for recovery after surgery, but is hard to gauge accurately. Doctors normally use signs such as heart rate and blood pressure to guide them, but these can be unreliable. Previous research has shown that a treatment used during surgery and shortly afterwards may improve the amount of oxygen delivered to the body’s tissues and reduce the number of patients who develop complications after surgery. This treatment involves using a heart monitor (cardiac output monitor) to help clinical teams decide the amount and timing of intravenous fluid to give to patients. There is some evidence from smaller studies that this treatment is beneficial, but this needs to be confirmed in a much larger study. The aim of this study is to find out whether the use of cardiac output monitoring to guide the use of intravenous fluid increases the number of days spent alive and out of hospital within 90 days of randomisation compared with usual care.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
2023 Protocol article in https://doi.org/10.1186/s13063-023-07275-3 (added 09/05/2023)
You can take part if:
You may not be able to take part if:
1. Refusal of patient consent2. Clinician refusal3. Previous enrolment in the FLO-ELA trial4. Previous inclusion in NELA within the current hospital admission5. Current participation in another clinical trial of a treatment with a similar biological mechanism6. Scheduled abdominal procedure outside the scope of NELA, including: elective procedures, uncomplicated appendicectomy or cholecystectomy, non-elective hernia repair without bowel resection, vascular surgery, including abdominal aortic aneurysm repair, Caesarean section, obstetric laparotomies or gynaecological laparotomy, or laparotomy/laparoscopy for pathology caused by trauma
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Mark
Edwards
-
admin@floela.org
Ms
Zoe
Clark
+44 (0)23 8120 1863
zoe.clark@uhs.nhs.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by University Hospital Southampton NHS Foundation Trust and funded by Health Technology Assessment Programme.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 33869
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
