Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Elena Ratschen
+44 (0)1904 320000
elena.ratschen@york.ac.uk


Dr Yan Ding
+44 (0)1904 32 5600
yan.ding@york.ac.uk


Prof Lion Shahab
+44 (0)20 7679 1805
lion.shahab@ucl.ac.uk


Study Location:

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Be Part of Research - Trial Details - E-cigarettes for smoking cessation and reduction in people with a mental illness
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E-cigarettes for smoking cessation and reduction in people with a mental illness

Not Recruiting

Open to: All Genders

Age: Adult

Shipley Darlington Sheffield Oxford Norwich Newcastle Upon Tyne Rotherham Rotherham York Sheffield Goole Sunderland Sunderland Goole Wakefield Nottingham Preston

Medical Conditions

Smoking cessation using an e-cigarette in patients living in the community who have a mental illness

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Tobacco smoking is the single largest contributor to health inequalities for people with mental illness (PWMI). Developing and implementing ways to address this widening health gap has been identified as a priority in the NHS Long Term Plan and the 2019 Tobacco Control Plan for England. E-cigarettes have been suggested as a potentially particularly helpful way to support people with mental illness quit smoking or substantially reduce consumption. However, there have been no fully powered trials to assess this potential. The researchers completed a feasibility study in January 2023 and are now ready to proceed to a full randomised controlled trial (RCT). The aim of this study is to assess the effectiveness and cost-effectiveness of providing an e-cigarette starter kit to PWMI treated in the community to aid smoking cessation and harm reduction.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

27 Mar 2024 31 Dec 2024

Interventional

Intervention Type : Device
Intervention Description : The intervention allocation will be determined by block computer randomisation to ensure that each trial site has an equal proportion of intervention and control group participants. Randomisation will occur after consent to take part in the study has been obtained via sealed envelope.

The intervention group will be offered an e-cigarette starter kit, compliant with EU regulation, and an information leaflet about e-cigarettes, in addition to usual care. A 20 mg/ml strength DOTPRO e-cigarette starter kit (https://www.liberty-flights.co.uk/DOT-PRO/DOT-PRO-Vape-Kit/) will be offered in a choice of flavours. The starter kit containing a pod-based e-cigarette, a 4-week supply of refill pods and an information leaflet will be provided to participants by their clinician at their scheduled appointment. At the scheduled appointment with a clinician, a brief consultation will also be conducted with participants to provide necessary instructions for the use of the kit lasting between 5-10 minutes. All participants will be encouraged to consider quitting and to set a target quit date within a week, told that smoking cessation is beneficial for their mental and physical health and that e-cigarettes are a safe and effective way to achieve smoking cessation.

The control group will receive care as usual, as outlined above and they will be told that smoking cessation is beneficial for their mental and physical health.



Adults (aged over 18 years) receiving treatment for a mental illness in primary or secondary care, who smoke regularly

You can take part if:



You may not be able to take part if:


1. Patients must not have had an inpatient admission in the last 3 months 2. Smokers who are currently using e-cigarettes regularly (at least weekly)3. Patients who are participating in other smoking cessation trials4. Patients who are receiving treatment for drug or alcohol use5. Patients who have a diagnosis of Alzheimer’s disease or dementia6. Patients who are pregnant or breastfeeding


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Bradford District Care NHS Foundation Trust
    New Mill Victoria Road Saltaire
    Shipley
    BD18 3LD
  • Tees, Esk and Wear Valleys NHS Foundation Trust
    Trust Headquarters West Park Hospital Edward Pease Way
    Darlington
    DL2 2TS
  • Sheffield Clinical Commissioning Group Hq
    722 Prince of Wales Road Darnall
    Sheffield
    S9 4EU
  • Oxford NHS Foundation Trust
    Littlemore Mental Health Centre Sandford Road Littlemore
    Oxford
    OX4 4XN
  • Norfolk and Suffolk NHS Foundation Trust
    County Hall Trust Headquarters Martineau Lane
    Norwich
    NR1 2DH
  • CRN North East and North Cumbria
    LCRN Level2 Regent Point Regent Farm Road Gosforth
    Newcastle Upon Tyne
    NE3 3HD
  • Woodstock Bower Surgery
    Kimberworth Road
    Rotherham
    S61 1AH
  • Clifton Medical Centre
    239 Doncaster Gate
    Rotherham
    S65 1DA
  • My Health
    Strensall Health Care Centre Southfields Road Strensall
    York
    YO32 5UA
  • Mosborough Health Centre
    Doctors Surgery 34 Queen Street Mosborough
    Sheffield
    S20 5BQ
  • Bartholomew Medical Group
    Goole Health Centre Woodland Avenue
    Goole
    DN14 6RU
  • Bridge View Medical Group
    Southwick Health Centre, The Green, Southwick
    Sunderland
    SR5 2LT
  • Springwell Medical Group
    Jack Cohen Health Centre, Springwell Road
    Sunderland
    SR3 4HG
  • Snaith and Rawcliffe Medical Group
    The Marshes Butt Lane Snaith
    Goole
    DN14 9DY
  • South West Yorkshire Partnership NHS Foundation Trust
    Fieldhead Ouchthorpe Lane
    Wakefield
    WF1 3SP
  • Nottinghamshire Healthcare NHS Foundation Trust
    Duncan Macmillan House Porchester Road
    Nottingham
    NG3 6AA
  • Lancashire and South Cumbria NHS Foundation Trust
    Sceptre Point Sceptre Way Walton Summit
    Preston
    PR5 6AW

Participants may make positive changes to their smoking behaviour and provide data which could help thousands of smokers to quit smoking for good. They will receive a shopping voucher each time they complete the follow-up questionnaires and receive an e-cigarette which they can keep.

Dr Yan Ding
+44 (0)1904 32 5600
yan.ding@york.ac.uk


Prof Lion Shahab
+44 (0)20 7679 1805
lion.shahab@ucl.ac.uk


Dr Elena Ratschen
+44 (0)1904 320000
elena.ratschen@york.ac.uk



The study is sponsored by University of York and funded by Yorkshire Cancer Research.



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Read full details for Trial ID: ISRCTN14068059

Or CPMS 58155

Last updated 09 April 2025

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