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Contact Information:

Claire Butler
c.e.butler@bham.ac.uk


Lisa Fuller
l.fuller.1@bham.ac.uk


Saffron King
s.king.8@bham.ac.uk


Adam Croft
a.p.croft@bham.ac.uk


Adam Croft
a.p.croft@bham.ac.uk


Miss Helen Williams
h.m.williams.1@bham.ac.uk


Kady Hutton
ras@uhb.nhs.uk


Study Location:

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Be Part of Research - Trial Details - Mechanisms of joint inflammation in childhood arthritis (version 1.0)

Mechanisms of joint inflammation in childhood arthritis (version 1.0)

Recruiting

Open to: Female / Male

Age: 42 Days - 30 Years

Medical Conditions

Inflammatory polyarthropathies


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Chronic arthritis of children, known as juvenile idiopathic arthritis (JIA), affects 1 in 10, 000 children, and is one of the leading causes of childhood-acquired disability. While some children experience self-limiting episodes of joint inflammation (pain and swelling) others develop a severe form of arthritis that can persist into adulthood. Understanding the disease mechanisms responsible for the persistence of joint inflammation will allow us to develop more targeted and effective treatments to be used early in the course of the disease, in order to prevent joint damage and disability. We now want to use ultrasound to help us to obtain synovial tissue from the lining of inflamed joints using keyhole techniques. These synovial tissue samples along with synovial fluid and peripheral blood will allow us to better understand the underlying mechanisms of disease severity, progression and treatment response.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

09 Aug 2021 09 Aug 2025

Observational

Observational type: Clinical Laboratory Study;



You can take part if:



You may not be able to take part if:


1. Symptoms or signs judged to be attributable solely to non-inflammatory joint disease. 2. Unable to provide informed consent.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Great Ormond Street Hospital Central London Site
    London
    Greater London
    WC1N 3JH
  • Birmingham Children's Hospital
    Birmingham
    West Midlands
    B4 6NH

Adam Croft
a.p.croft@bham.ac.uk


Saffron King
s.king.8@bham.ac.uk


Miss Helen Williams
h.m.williams.1@bham.ac.uk


Claire Butler
c.e.butler@bham.ac.uk


Lisa Fuller
l.fuller.1@bham.ac.uk


Adam Croft
a.p.croft@bham.ac.uk


Kady Hutton
ras@uhb.nhs.uk



The study is sponsored by University of Birmingham and funded by VERSUS ARTHRITIS; THE KENNEDY TRUST FOR RHEUMATOLOGY RESEARCH; .





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for Trial ID: CPMS 48969

Last updated 04 June 2025

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