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Be Part of Research - Trial Details - REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

Medical Conditions

Cardiovascular Diseases


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2023 Sep 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Participants will receive cagrilintide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

Intervention Arm Group : CagriSema;

Intervention Type : DRUG
Intervention Description : Participants will receive semaglutide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

Intervention Arm Group : CagriSema;

Intervention Type : DRUG
Intervention Description : Participants will receive placebo matched to cagrilintide and placebo matched to semaglutide subcutaneously.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Ninewells Hospital
    Dundee
    DD1 9SY
  • Southmead Hospital
    Bristol
    BS10 5NB
  • Bradford Royal Infirmary
    Bradford
    BD9 6RJ
  • Western General Hospital
    Edinburgh
    EH4 2XU
  • Hull Royal Infirmary
    Hull
    HU3 2JZ
  • East Surrey Hospital
    Redhill
    RH1 5RH
  • Leicester General Hospital
    Leicester
    LE5 4PW
  • Countess of Chester Hospital
    Chester
    CH2 1UL
  • Blackpool Victoria Hospital
    Blackpool
    Lancashire
    FY3 8NR
  • Clifton Medical Centre
    Rotherham
    S65 1DA
  • The Good Practice
    London
    SW10 0LR
  • The Health Centre
    Bradford-on-Avon
    BA15 1DQ
  • University Hospitals of Coventry and Warwickshire NHS Trust
    Coventry
    CV2 2DX
  • Intelligent Clinical
    Glasgow
    G20 0XA
  • The Diabetes Centre
    Ipswich
    IP4 5PD
  • The Staploe Medical Centre
    Soham
    CB7 5JD
  • Royal Cornwall Hospital (Treliske)
    Truro
    TR1 3LJ
  • St. Richards Hospital
    Chichester
    West Sussex
    PO19 6SE
  • University Dept of Medicine, Derriford Hospital, Plymouth
    Plymouth
    PL6 5FP
  • Diabetes Centre, Heartlands Hospital, Birmingham
    Birmingham
    West Midlands
    B9 5SS
  • Patient Recruitment Centre: Newcastle
    Newcastle upon Tyne
    NE1 4LP
  • Royal Devon University Healthcare NHS Foundation Trust
    Exeter
    EX2 5DW


The study is sponsored by Novo Nordisk A/S




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Read full details for Trial ID: NCT05669755
Last updated 22 July 2025

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