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Be Part of Research - Trial Details - A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis

A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis

Medical Conditions

Gastroenteritis


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prevent protocol-defined moderate or severe norovirus acute gastroenteritis (AGE) associated with vaccine matched genotypes.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2024 May 2027

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : Intramuscular (IM) injection.

Intervention Arm Group : mRNA-1403;

Intervention Type : BIOLOGICAL
Intervention Description : 0.9% sodium chloride solution by IM injection.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Manchester University NHS Foundation Trust
    Manchester
  • University Hospitals of Leicester NHS Trust
    Leicester
  • NHS Grampian - Aberdeen Royal Infirmary
    Aberdeen
  • NHS Lothian - Western General Hospital
    Edinburgh
  • Royal Devon & Exeter Hospital (Wonford)
    Exeter
  • Glasgow Clinical Research Facility
    Glasgow
  • Accellacare Warwickshire Quality Research Site
    Coventry
  • Weymouth Research Hub
    Weymouth
  • Lakeside Healthcare
    Corby
    Northamptonshire
  • Velocity Clinical Research - High Wycombe
    High Wycombe
    Buckinghamshire
  • Warrington and Halton Teaching Hospitals NHS Foundation Trust - Halton General Hospital
    Runcorn
    Cheshire
  • Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital
    Truro
    Cornwall
  • St George's University Hospitals NHS Foundation Trust - St George's Hospital
    London
    England
  • Accellacare South London
    Orpington
    Kent
  • Layton Medical Centre
    Blackpool
    Lancashire
  • Panthera Biopartners - Manchester
    Rochdale
    Manchester
  • Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital
    Salford
    Manchester
  • Eynsham Medical Center
    Witney
    Oxfordshire
  • NIHR Welcome Trust Clinical Research Facility
    Birmingham
  • Bournemouth Research Hub
    Bournemouth
  • North Bristol NHS Trust - Southmead Hospital
    Bristol
  • Cardiff and Vale University Health Board - University Hospital Wales
    Cardiff
  • Panthera Biopartners - North London
    Enfield Town
  • CPS Research by FutureMeds
    Glasgow
  • Panthera Biopartners - Glasgow
    Glasgow
  • FutureMeds Wirral
    Liverpool
  • Mile End Hospital
    London
  • Royal Free London NHS Foundation Trust - Royal Free Hospital
    London
  • FutureMeds Newcastle
    Newcastle upon Tyne
  • Leeds Teaching Hospitals NHS Trust - St James' University Hospital
    Nottingham
  • Plymouth Hospital NHS trust-Derriford Hospital
    Plymouth
  • Portsmouth Research Hub
    Portsmouth
  • Panthera Biopartners - Sheffield
    Sheffield
  • Accellacare Yorkshire Quality Research Site
    Shipley
  • Wansford Research Ltd
    Wansford
  • Windrush Medical Practice
    Witney
  • North Wales Clinical Research Centre (NWCRC)
    Wrexham
  • Panthera Biopartners - York
    York
  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust
    Newcastle upon Tyne


The study is sponsored by ModernaTX, Inc.




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Read full details for Trial ID: NCT06592794
Last updated 27 June 2025

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