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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Study Contact 844-434-4210
Participate-In-This-Study@its.jnj.com


Study Location:

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Be Part of Research - Trial Details - Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Anemia
Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune
Hemolysis


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The main purpose of this study is to evaluate the efficacy and safety of M281 in participants with warm autoimmune hemolytic anemia (wAIHA).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2019 Mar 2025

Publications

"Liu AP, Cheuk DK. Disease-modifying treatments for primary autoimmune haemolytic anaemia. Cochrane Database Syst Rev. 2021 Mar 26;3(3):CD012493. doi: 10.1002/14651858.CD012493.pub2."; "33786812"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : M281 injection administered as intravenous infusion

Intervention Arm Group : M281 administered every 2 weeks (double-blind period);M281 administered every 2 weeks (open-label extension period);M281 administered every 4 weeks (double-blind period);M281 administered every 4 weeks (open-label extension period);

Intervention Type : DRUG
Intervention Description : Placebo administered as intravenous infusion

Intervention Arm Group : M281 administered every 4 weeks (double-blind period);Placebo administered every 2 weeks (double-blind period);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Barts Health NHS Trust
    London
    E1 2ES
  • University Hospitals Plymouth NHS Trust
    Plymouth
    PL6 8DH
  • Oxford University Hospitals NHS Foundation Trust
    Oxford
    OX3 7LE
  • University Hospital Southampton NHS Foundation Trust
    Southampton
    SO166YD
  • Liverpool University Hospitals NHS Foundation Trust
    Liverpool
    L7 8XP
  • Leeds Teaching Hospitals NHS Trust
    Leeds
    LF9 7TF


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT04119050
Last updated 28 March 2025

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