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Be Part of Research - Trial Details - A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

Not Recruiting

Open to: ALL

Age: 18.0 - 130.0

Medical Conditions

Lung Neoplasms
Carcinoma, Non-Small-Cell Lung


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will assess the efficacy and safety of the combination of ceralasertib and durvalumab versus standard of care docetaxel in patients with locally advanced and metastatic NSCLC after progression on prior anti-PD-(L)1 therapy and platinum-based chemotherapy.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2022 Aug 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Participants will receive ceralasertib oral tablets.

Intervention Arm Group : Group A: Ceralasertib plus durvalumab combination therapy;

Intervention Type : DRUG
Intervention Description : Participants will receive durvalumab as an intravenous infusion.

Intervention Arm Group : Group A: Ceralasertib plus durvalumab combination therapy;

Intervention Type : DRUG
Intervention Description : Participants will received docetaxel as an intravenous infusion.

Intervention Arm Group : Group B: Docetaxel monotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Sutton
    SM2 5PT
  • Research Site
    Wirral
    CH63 4JY
  • Research Site
    Stevenage
    SG1 4AB
  • Research Site
    Guildford


The study is sponsored by AstraZeneca and is in collaboration with Parexel.




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Read full details for Trial ID: NCT05450692
Last updated 01 July 2025

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