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Be Part of Research - Trial Details - Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial

Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial

Completed

Open to: ALL

Age: 18.0 - 65.0

Medical Conditions

Schizophrenia
Stress Disorders, Traumatic
Psychotic Disorders
Mental Disorders
Stress Disorders, Post-Traumatic


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Psychosis is a highly distressing mental health condition, affecting up to 3% of the population. Conceptually, it has much in common with complex post-traumatic stress disorder (CPTSD), a recently introduced condition in ICD-11. Both involve negative self-esteem, impaired emotion regulation ability, interpersonal difficulties and intrusive trauma- related experiences (i.e. intrusive thoughts, flashbacks, nightmares). Both have been causally related to childhood trauma, such as abuse, neglect and loss.

The current project will examine the feasibility of conducting an 'Umbrella trial' to test whether CPTSD is causally related to psychosis, and develop more effective trauma-focused psychological interventions for psychotic symptoms by treating underlying experiences of/reactions to trauma. An Umbrella trial involves running several individual randomised controlled trials concurrently. In this study, each trial will test whether psychological interventions designed to reduce different CPTSD symptoms cause improvements in psychotic symptoms. If the investigators can establish feasibility of this Umbrella trial, and if a definitive version shows that interventions for CPTSD also reduce psychosis, then this would be a breakthrough in both the conceptualisation and treatment of psychosis which will help transform the care of people with psychosis. Demonstrating the feasibility of our proposed methodology would also help to accelerate the development of interventions for other mental health problems.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2022 Aug 2023

INTERVENTIONAL

Intervention Type : BEHAVIORAL
Intervention Description : See relevant study arm for description

Intervention Arm Group : Affect Dysregulation intervention;

Intervention Type : BEHAVIORAL
Intervention Description : See relevant study arm for description

Intervention Arm Group : Negative Self Concept intervention;

Intervention Type : BEHAVIORAL
Intervention Description : See relevant study arm for description

Intervention Arm Group : Disturbed Relationships intervention;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • NHS Lothian
    Edinburgh
  • NHS Greater Glasgow & Clyde
    Glasgow


The study is sponsored by Edinburgh Napier University and is in collaboration with NHS Lothian; NHS Greater Glasgow and Clyde; University of Glasgow; University of Sheffield; University of Manchester; University of Ulster.




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Read full details for Trial ID: NCT05281640
Last updated 22 February 2024

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