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Contact Information:

Prof Glen Davison
+44 (0)1227816927
G.Davison@kent.ac.uk


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Be Part of Research - Trial Details - Does ColdZyme mouth spray protect athletes against upper respiratory tract infection?
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Does ColdZyme mouth spray protect athletes against upper respiratory tract infection?

Not Recruiting

Open to: All Genders

Age: Adult

Derby Canterbury Newcastle upon Tyne

Medical Conditions

Upper respiratory tract infection (URTI) in healthy, free-living athletes

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Endurance athletes appear to be more susceptible than normal to picking up infections, especially upper respiratory tract infections (URTI). Symptoms such as coughs, colds, sore throat, runny nose etc can last for up to 2 weeks, and inevitably cause disruption to training schedules and competitive performance. For this reason, researchers are interested in treatments that may reduce the risk of such illness/symptoms in athletes. They wish to test whether a mouth spray product (ColdZyme) suggested to ‘block’ the viruses that cause the common cold from attaching to cell surfaces in the respiratory tract, can lower the duration of symptoms and/or the number of reports of upper respiratory illness in endurance athletes.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Oct 2022 01 Feb 2024

Publications

2025 Results article in https://doi.org/10.1113/JP288136 (added 03/03/2025)

If they agree to take part, participants would be required to complete a health questionnaire to ensure they are suitable for participation, and to sign a consent form. For the duration of the monitoring period (3 months) they would be required to keep a log of all of their exercise training. They will also be required to complete a daily upper respiratory tract infection (URTI) symptom questionnaire. Finally, if they do experience any URTI symptoms, they are asked to take a self-swab from their throat using a swabbing device for later analysis (to detect any viruses or bacteria that are known to cause URTIs).
Participants will be asked to use the product in accordance with manufacturer instructions for routine preventative use and for treatment of any suspected URTI as detailed below:
1. Preventative use: "during periods when you think you may be at increased risk or have increased chances of being exposed to a cold, such as heavy training or competition periods, foreign travel or exposure to infected individuals"
2. Treatment if a URTI does occur, e.g. at the first signs of a cold.


Endurance athletes (both males and females) over the age of 18 years with at least 3 years of endurance training history and no existing medical conditions

You can take part if:



You may not be able to take part if:


1. On long-term medication2. Currently smoking3. Allergic to any of the ingredients in ColdZyme4. Currently using any medication (except for contraceptives), or food supplements5. Currently using any other relevant products or supplements (nutritional or otherwise) that may influence the common cold6. Currently taking part in another study that may compromise the results of this study7. Currently pregnant, breast-feeding or planning to become pregnant during the study


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Derby
    Kedleston Road
    Derby
    DE22 1GB
  • University of Kent
    School of Sport & Exercise Sciences Chipperfield Building
    Canterbury
    CT2 7PE
  • Newcastle University
    Newcastle upon Tyne
    NE2 4DR

The product should not cause any side effects or adverse reactions for anybody that is not allergic to any of the ingredients listed in the product. However, if participants experience any adverse response, they are advised to stop use immediately and seek medical advice. This would be reported to the sponsor, manufacturer, and ethics committee for appropriate reporting. Taking the throat swab may cause mild discomfort (e.g. some people find a throat swab either tickly or a bit unpleasant) but this only lasts a few seconds. There are no significant long-term risks from this.

Prof Glen Davison
+44 (0)1227816927
G.Davison@kent.ac.uk



The study is sponsored by University of Kent and funded by Enzymatica AB.



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Read full details for Trial ID: ISRCTN18133939
Last updated 03 March 2025

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