Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Miss Nikki Blythe
+44 (0)117 394 0250
comited-trial@bristol.ac.uk


Prof Edward Carlton
+44 (0)7595 040112
Ed.Carlton@nbt.nhs.uk


Prof Edward Carlton
+44 (0)7595 040112
Ed.Carlton@nbt.nhs.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - CoMiTED: investigating whether a collapsed lung (pneumothorax) due to injury (trauma) can be safely and effectively treated without immediately inserting a tube into the chest (chest drain)

CoMiTED: investigating whether a collapsed lung (pneumothorax) due to injury (trauma) can be safely and effectively treated without immediately inserting a tube into the chest (chest drain)

Medical Conditions

Traumatic pneumothorax


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


A collapsed lung (also known as a ‘pneumothorax’) can occur following trauma such as falls, road traffic accidents, or knife injuries. We are doing a study to compare different treatment options for a collapsed lung. Currently, doctors treat this condition by inserting a tube (chest drain) through the chest wall, to help the lung re-inflate. Every year, around 25,000 patients in England and Wales have a chest drain inserted. We think that more patients with a collapsed lung could be safely treated without a chest drain, but there is currently no good research evidence one way or the other. The National Institute for Health Research (NIHR) identified this as an area of need and funded our research study to answer the question.

Both treatments for a collapsed lung (treatment with or without a chest drain) have advantages and disadvantages, but we do not know if one is better than the other. This research will help us find out which treatment is better and whether doctors should change their practice and potentially treat fewer patients with a chest drain.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

08 Aug 2022 31 Jan 2025

Publications

2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38889939/ (added 19/06/2024)

Participants, when they join the study, will be put into one of two groups. One group will have treatment with a chest drain (current usual care) and the other group will be treated without a chest drain to start with. Participants will be allocated randomly (like tossing a coin) and have an equal chance of receiving either treatment. All participants will be assessed and monitored according to the usual care of the hospital.

Participants will complete questionnaires at 30 days, 3, and 6 months and the study team will review their medical notes.


Patients aged 16 years or older who have been admitted to the Accident and Emergency department (A&E), with a collapsed lung due to injury.

You can take part if:



You may not be able to take part if:


1. Treating clinician(s) believe injuries are incompatible with life2. Respiratory arrest3. Haemothorax requiring a chest drain in the opinion of the treating clinician(s)4. Clinical and imaging evidence of tension pneumothorax 5. Prisoners (does not include those in police custody; only those detained in prison establishments)6. Retrospective paediatric exclusion if patient confirmed to be aged <16 years


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • North Bristol NHS Trust
    Southmead Hospital Southmead Road Westbury-on-trym
    Bristol
    BS10 5NB
  • Sheffield Teaching Hospitals NHS Foundation Trust
    Northern General Hospital Herries Road
    Sheffield
    S5 7AU
  • St George's University Hospitals NHS Foundation Trust
    St George's Hospital Blackshaw Road Tooting
    London
    SW17 0QT
  • Musgrove Park Hospital (taunton)
    Musgrove Park Hospital
    Taunton
    TA1 5DA
  • Torbay And South Devon NHS Foundation Trust
    Torbay Hospital Newton Road
    Torquay
    TQ2 7AA
  • Royal Berkshire NHS Foundation Trust
    Royal Berkshire Hospital London Road
    Reading
    RG1 5AN
  • University Hospital of Wales
    Heath Park
    Cardiff
    CF14 4XW
  • Northwick Park Hospital
    Watford Road
    Harrow
    HA1 3UJ
  • John Radcliffe Hospital
    Headley Way Headington
    Oxford
    OX3 9DU
  • Southampton General Hospital
    Tremona Road
    Southampton
    SO16 6YD
  • James Cook University Hospital
    Marton Road
    Middlesbrough
    TS4 3BW
  • Hull Royal Infirmary
    Anlaby Road
    Hull
    HU3 2JZ
  • Addenbrookes
    Addenbrookes Hospital Hills Road
    Cambridge
    CB2 0QQ
  • Leeds General Infirmary
    Great George Street
    Leeds
    LS1 3EX
  • Royal Cornwall Hospitals NHS Trust
    Royal Cornwall Hospital Treliske
    Truro
    TR1 3LJ
  • Barts Health NHS Trust
    The Royal London Hospital 80 Newark Street
    London
    E1 2ES
  • The Royal Victoria Infirmary
    Queen Victoria Road
    Newcastle upon Tyne
    TS1 4LP
  • Victoria Hospital
    Hayfield Road
    Kirkcaldy
    KY2 5AH
  • Aintree University Hospital
    Lower Lane
    Liverpool
    L9 7AL
  • Bristol Royal Infirmary
    Marlborough Street
    Bristol
    BS2 8HW
  • Princess Alexandra Hospital
    Hamstel Road
    Harlow
    CM20 1QX
  • University Hospital (coventry)
    Clifford Bridge Road
    Coventry
    CV2 2DX
  • Milton Keynes University Hospital
    Standing Way Eaglestone
    Milton Keynes
    MK6 5LD
  • University Hospitals Plymouth NHS Trust
    Derriford Hospital Derriford Road Derriford
    Plymouth
    PL6 8DH
  • Poole Hospital
    Longfleet Road
    Poole
    BH15 2JB
  • West Suffolk Hospital
    Hardwick Lane
    Bury St Edmunds
    IP33 2QZ
  • Northumbria Healthcare NHS Foundation Trust
    North Tyneside General Hospital Rake Lane
    North Shields
    NE29 8NH
  • Northumbria Specialist Emergency Care Hospital
    Northumbria Way
    Cramlington
    NE23 6NZ
  • Royal United Hospital
    Combe Park
    Bath
    BA1 3NG
  • Gloucestershire Royal Hospital
    Great Western Road
    Gloucester
    GL1 3NN
  • Broomfield Hospital
    Court Road Broomfield
    Chelmsford
    CM1 7ET
  • Queen Elizabeth Hospital
    Edgbaston
    Birmingham
    B15 2TH
  • St Mary’s Hospital
    Praed Street
    London
    W2 1NY
  • Tunbridge Wells Hospital
    The Tunbridge Wells Hospital Tonbridge Road Pembury
    Tunbridge Wells
    TN2 4QJ
  • Prince Charles Hospital
    Merthyr/cynon Unit
    Merthyr Tydfil
    CF47 9DT
  • Watford General Hospital
    60 Vicarage Road
    Watford
    WD18 0HB
  • Macclesfield District General Hospital
    Macclesfield District Hospital Victoria Road
    Macclesfield
    SK10 3BL
  • The Grange University Hospital
    Caerleon Road
    Cwmbran
    NP44 8YN
  • Manchester University NHS Foundation Trust
    Manchester Royal Infirmary Cobbett House Oxford Road
    Manchester
    M13 9WL
  • University College London
    University College London Hospitals NHS Foundation Trust 250 Euston Road
    London
    NW1 2PG
  • The Royal Victoria Hospital
    Grosvenor Road
    Belfast
    BT12 6BA
  • The Royal Infirmary of Edinburgh
    51 Little France Crescent
    Edinburgh
    EH16 4SA
  • Royal Liverpool University Hospital
    Royal Liverpool University Hospital NHS Trust Prescot Street
    Liverpool
    L7 8XP

In general, the trial will not expose participants to risks additional to routine care. The trial will, however, expose trauma victims to the potential downsides of the established pathways used in clinical practice: those allocated to usual care may have a chest drain inserted without the opportunity for conservative management (and potentially unnecessarily), while a proportion of those allocated to conservative management may be perceived as suffering a delay to the insertion of chest drain that becomes necessary at a later stage in their care. This is supported by PPI. Study procedures will include questionnaires at each time point. This will use the participant's time, but no other inconvenience or risk is expected. The questionnaires have been reviewed by our PPI team to ensure they are acceptable to patients.
By taking part in this study, participants will help to demonstrate whether conservative management is effective and cost-effective in the initial management of traumatic pneumothoraces. This may help and influence the treatment of patients in the future.

Prof Edward Carlton
+44 (0)7595 040112
Ed.Carlton@nbt.nhs.uk


Prof Edward Carlton
+44 (0)7595 040112
Ed.Carlton@nbt.nhs.uk


Miss Nikki Blythe
+44 (0)117 394 0250
comited-trial@bristol.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by North Bristol NHS Trust and funded by National Institute for Health Research; Health Technology Assessment Programme.




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: ISRCTN35574247

Or CPMS 52683

Last updated 11 March 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.