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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Jamie
Hall
+44 (0)114 222 2963
jamie.hall@sheffield.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
Crohn’s disease
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Crohn’s is a disease that makes the bowel red, swollen and painful. It is a lifelong disease. Some people get few flare-ups. Other people may have really bad and long-lasting symptoms. There is no cure for Crohn’s, but drugs can treat the symptoms. If the drugs do not work surgery may be needed. Whilst surgery can also stop symptoms for a long time, the disease can return. Further drugs and even further surgery may be needed. Many surgeons feel that the way the bowel and the tissue containing the blood and other vessels supplying the bowel (the mesentery) is removed and the way the healthy bowel ends are re-joined can affect the success of surgery. Two changes to the way surgeons operate have been proposed. One involves taking out more of the mesentery and the other involves doing another type of bowel join. This is known as the Kono-S join. They are safe but researchers need to test that they are better than the usual method in stopping further disease. In this study the researchers will ask people if they would let them carry out one or both of these methods. They will then see if they have reduced the chances of further disease 1 year later. The type of surgery a person has will be decided by chance.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
Participant exclusion criteria as of 10/11/2023: 1. Patients with markedly extensive inflammation affecting the vascular root of the mesentery seen on imaging or at operation2. Patients undergoing stoma formation proximal to the anastomosis3. Patients who have a contraindication to subsequent colonoscopy4. Patients unable to give full informed consent5. Patients who are pregnant (as ascertained by standard pregnancy tests undertaken at preoperative visits as per standard clinical care)6. Patients who, in the opinion of the principal investigator, do not meet the criteria for relevant surgery
Previous participant exclusion criteria:1. Patients with markedly extensive inflammation affecting the vascular root of the mesentery seen on imaging or at operation2. Patients undergoing stoma formation3. Patients who have a contraindication to subsequent colonoscopy4. Patients unable to give full informed consent5. Patients who are pregnant (as ascertained by standard pregnancy tests undertaken at preoperative visits as per standard clinical care)6. Patients who, in the opinion of the principal investigator, do not meet the criteria for relevant surgery
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Jamie
Hall
+44 (0)114 222 2963
jamie.hall@sheffield.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by Sheffield Teaching Hospitals NHS Foundation Trust and funded by NIHR Evaluation, Trials and Studies Co-ordinating Centre (NETSCC); Grant Codes: NIHR131988.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 52048
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
