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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Miss
Hollie
Wilkes
ctru-chart@leeds.ac.uk
Prof
Andrew
Clegg
a.p.clegg@leeds.ac.uk
Prof
Victoria
Goodwin
v.goodwin@exeter.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
Older people living with heart failure with preserved ejection fraction and frailty
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Frailty is a condition that is common in older age. It develops because as we get older our bodies change and can lose their resilience. This means that older people with frailty can experience sudden, dramatic changes in their wellbeing when they have health problems. Heart failure (HF) is a complex condition where the heart muscle doesn’t pump blood as well as it should because it has become too weak or stiff. People with heart failure with preserved ejection fraction (HFpEF) have symptoms of heart failure even though their heart pumps blood well.
Current NHS services are not well developed for people who have multiple health problems. This means people with frailty and HFpEF may not receive the right sort of care they need. Comprehensive Geriatric Assessment (CGA) involves older people as well as their families, carers and healthcare professionals to identify and help manage multiple health problems and prevent new ones arising. Rehabilitation helps people to do what is important to them.
Our research aims to work out if, CGA (including rehabilitation at home) in addition to usual care helps frail older people with HFpEF maintain their ability to carry out everyday activities. This will be compared to people getting usual care alone.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
Current inclusion criteria as of 04/11/2025:
1. Aged ≥65 years
2. Clinical diagnosis of HFpEF*
3. Mild, moderate or severe frailty based on the Clinical Frailty Scale (CFS 5-7)
4. Capacity to provide informed consent (assessed prior to registration)
5. Most recent echocardiogram within the last 2 years and showing LVEF ≥50%
*Diagnosis confirmed by a cardiology specialist. Retrospective identification from clinic letters is a reasonable reference standard as this diagnosis will have been based on guideline sta
You may not be able to take part if:
Current exclusion criteria as of 28/01/2025:
1. Not frail (as determined by a score on CFS 1-4); 2. Very severe frailty (CFS 8);3. Terminally ill with an anticipated life expectancy of < 6 months ; 4. Care home resident; 5. Unstable angina*; 6. New York Heart Association (NYHA) class IV HF (assessed after registration by a CHART researcher); 7. Another household member participating in the trial**; 8. Moderate/severe cognitive impairment (Face-to-face Montreal Cognitive Assessment MoCA score of <18 or Blind Montreal Cognitive Assessment MoCA score of <13) (assessed after registration by a CHART researcher) 9. Significant alternative valvular/structural cardiac disease to explain symptoms***;10. Current hospitalisation or within the last 3 months with decompensated heart failure11. Referred or receiving CGA and/or exercise-based rehabilitation as part of a clinical service or another research project****.*A CHART researcher will ask the participant at time of registration whether they have angina and then ask if they have symptoms at rest to determine eligibility. **A CHART researcher will ask the participant at time of registration whether anyone in their household is also participating in CHART. ***Valve disease exclusions include: severe aortic stenosis, severe aortic regurgitation, severe mitral regurgitation, moderate or severe mitral stenosis. Participants with these exclusions will be screened out prior to initial approach for the study. **** Patients referred to or currently being seen in community frailty services, outpatient geriatric medicine services or outpatient/community falls prevention services. A CHART researcher will assess through discussion with the potential participant
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Previous exclusion criteria:
1. Not frail (as determined by a score on CFS 1-4); 2. Very severe frailty (CFS 8);3. Terminally ill (CFS 9); 4. Care home resident; 5. Unstable angina*; 6. New York Heart Association (NYHA) class IV HF (assessed after registration by a CHART researcher); 7. Another household member participating in the trial**; 8. Moderate/severe dementia (Montreal Cognitive Assessment MoCA score < 18) (assessed after registration by a CHART researcher);9. Under regular review from geriatric medicine services;10. Significant alternative valvular/structural cardiac disease to explain symptoms***;11. Current hospitalisation with decompensated heart failure12. Receiving or referred for CGA as part of a clinical service or another research project****.
*A CHART researcher will ask the participant at time of registration whether they have angina and then ask if they have symptoms at rest to determine eligibility.**A CHART researcher will ask the participant at time of registration whether anyone in their household is also participating in CHART.***Valve disease exclusions include: severe aortic stenosis, severe aortic regurgitation, severe mitrial regurgitation, moderate or severe mitral stenosis. Participants with these exclusions will be screened out prior to initial approach for the study.****Patients seen in community frailty services, outpatient geriatric services, outpatient clinic-based falls services will be screened out prior to study invitation. CHART researchers will do a further check of involvement in these services prior to randomisation.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
Victoria
Goodwin
v.goodwin@exeter.ac.uk
Prof
Andrew
Clegg
a.p.clegg@leeds.ac.uk
Miss
Hollie
Wilkes
ctru-chart@leeds.ac.uk
More information about this study, what is involved and how to take part can be found on the study website.
The study is sponsored by Bradford Teaching Hospitals NHS Foundation Trust and funded by NIHR Evaluation, Trials and Studies Co-ordinating Centre (NETSCC).
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
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