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Be Part of Research - Trial Details - Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Medical Conditions

Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2024 Apr 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Zilebesiran administered by subcutaneous (SC) injection

Intervention Arm Group : Zilebesiran;

Intervention Type : DRUG
Intervention Description : Placebo administered by SC injection

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Trial Site
    Chorley
  • Clinical Trial Site
    Birmingham
  • Clinical Trial Site
    London
    SE1 1YR
  • Clinical Trial Site
    Liverpool
  • Clinical Trial Site
    London
    SW17 0RE
  • Clinical Trial Site
    Bellshill
    Lanarkshire
    ML4 3NJ
  • Clinical Trial Site
    Fowey
    Cornwall
    PL23 1DT
  • Clinical Trial Site
    Newquay
    Cornwall
    TR1 3HD
  • Clinical Trial Site
    Torpoint
    Cornwall
    PL11 2JW
  • Clinical Trial Site
    Chesterfield
    Derbyshire
    S40 4AA
  • Clinical Trial Site
    Plymouth
    Devon
    PL5 3JB
  • Clinical Trial Site
    London
    EC1M 6BQ
  • Clinical Trial Site
    Luton
    Bedfordshire
  • Clinical Trial Site
    Manchester
    Lancashire
  • Clinical Trial Site
    Glasgow
    Scotland
  • Clinical Trial Site
    Carshalton
    Surrey
  • Clinical Trial Site
    Hexham
    Northumberland
  • Clinical Trial Site
    Cardriff
  • Clinical Trial Site
    Pickering
  • Clinical Trial Site
    Leicester
    Leicestershire
  • Clinical Trial Site
    Luton
    Bedfordshire
    LU4 0DZ
  • Clinical Trial Site
    Liskeard
    Cornwall
    PL14 3XA
  • Clinical Trial Site
    Bristol
    Gloucestershire
    BS2 8ED
  • Clinical Trial Site
    Canterbury
    Kent
    CT1 3NG
  • Clinical Trial Site
    Glasgow
    Lanarkshire
    G11 5JT


The study is sponsored by Alnylam Pharmaceuticals




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Read full details for Trial ID: NCT06272487
Last updated 15 May 2025

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