Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Medical Conditions

High Cardiovascular Risk
Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2024 Jun 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Zilebesiran administered by subcutaneous (SC) injection

Intervention Arm Group : Zilebesiran;

Intervention Type : DRUG
Intervention Description : Placebo administered by SC injection

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Trial Site
    Leicester
    LE5 4PW
  • Clinical Trial Site
    Glasgow
    G51 4TF
  • Clinical Trial Site
    London
    SW17 0QT
  • Clinical Trial Site
    London
    SE1 1YR
  • Clinical Trial Site
    Bellshill
    ML4 3NJ
  • Clinical Trial Site
    Cardiff
    CF15 9SS
  • Clinical Trial Site
    Manchester
    M15 6SE
  • Clinical Trial Site
    Birmingham
    B15 2SQ
  • Clinical Trial Site
    Glasgow
    G20 7BE
  • Clinical Trial Site
    London
    EC1A 7BE
  • Clinical Trial Site
    Hexham
    NE46 1QJ
  • Clinical Trial Site
    Bristol
    BS2 8HW
  • Clinical Trial Site
    Canterbury
    CT1 3NG
  • Clinical Trial Site
    Carshalton
    SM5 1AA
  • Clinical Trial Site
    Chesterfield
    S40 4AA
  • Clinical Trial Site
    Chorley
    PR7 7NA
  • Clinical Trial Site
    Fowey
    PL23 1DT
  • Clinical Trial Site
    Liskeard
    PL14 3XA
  • Clinical Trial Site
    Liverpool
    L22 0LG
  • Clinical Trial Site
    Luton
    LU4 0DZ
  • Clinical Trial Site
    Newquay
    TR7 1RU
  • Clinical Trial Site
    Pickering
    YO18 8BL
  • Clinical Trial Site
    Plymouth
    PL5 3JB
  • Clinical Trial Site
    Torpoint
    PL11 2TB


The study is sponsored by Alnylam Pharmaceuticals




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT06272487
Last updated 27 February 2026

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.