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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Linda Sharp
+44 (0)1912086275
SWEET@warwick.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - Supporting women with adherence to hormone therapy following breast cancer

Supporting women with adherence to hormone therapy following breast cancer

Medical Conditions

Breast cancer


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In 2016, 11,563 women died from breast cancer in the UK. Most would have been prescribed hormone therapy (HT); sometimes known as endocrine therapy, which blocks the effect of oestrogen on breast cancer cells. HT is prescribed as a daily tablet, usually for at least 5 years and often up to 10 years. When women stop taking HT prematurely, or don’t take it as prescribed (known as “poor adherence”), they have up to a three times higher chance of the cancer returning and dying from cancer. At least 20% of women have poor adherence after 2 years and around 50% by 5 years. Previous research has identified reasons for poor adherence, including feeling negative or concerned about HT; not fully understanding its importance; side-effects; feeling unsupported; and forgetfulness. SWEET is an NIHR-funded research programme which, supported by a Patient Advisory Group and Clinical Reference Group, will develop and test a support package to support women taking treatment as recommended. The aim of this study is to determine the clinical effectiveness of the trial intervention in reducing poor adherence to treatment and improving quality of life.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

26 Mar 2024 31 Dec 2025

Participants randomly allocated to Group A will receive access to the HT&Me Support Package which involves:
A consultation of around 30 minutes with a HT&Me study nurse (either based at your local hospital site, or via the charity Breast Cancer Now) to discuss hormone therapy, answer any questions you might have and introduce the HT&Me website. This appointment may be delivered in person, by video call or if required by telephone call, appointments with a Breast Cancer Now nurse will always be completed over video call.
Access to the HT&Me website which contains short videos, information, tips & tools to support you to take hormone therapy every day (e.g. set reminders to take hormone therapy or order repeat prescriptions), get tips for managing side effects, and information about how to get further support.
After 12 weeks, participants will have a follow-up consultation with the HT&Me study nurse to see how they are getting on with their hormone therapy and the HT&Me website. For a few women, the researchers might record their consultations; this is simply to check what information they have been given and that the consultations are going as planned. They may also be asked to provide feedback on the appointments by text message.
Participants will also be sent some messages by email or text, to remind them about the importance of taking hormone therapy and that the website may be a useful resource.
Participants randomly allocated to Group B will continue with their usual NHS care and hormone therapy as prescribed.


Women recently diagnosed with ER-positive invasive breast cancer, stages 1- 3 and treated with curative intent, who have been prescribed oral adjuvant endocrine therapy (AET) within the past 3 months

You can take part if:



You may not be able to take part if:


1. Male2. Evidence of metastatic disease i.e. stage 4 disease (M1 regardless of T and N status)3. Have cognitive impairment sufficient to preclude participation, as judged by the clinical team4. Had previous AET (for another breast cancer)5. Are unable to read and understand English


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Beatson West of Scotland Cancer Centre
    1053 Great Western Road
    Glasgow
    G12 0YN
  • Musgrove Park Hospital (taunton)
    Musgrove Park Hospital
    Taunton
    TA1 5DA
  • Royal Sussex County Hospital
    Eastern Road
    Brighton
    BN2 5BE
  • Mount Vernon Cancer Centre
    Rickmansworth Road
    Northwood
    HA6 2RN
  • James Cook University Hospital
    Marton Road
    Middlesbrough
    TS4 3BW
  • Glan Clwd Hospital
    Ysbyty Glan Clwydd Bodelwyddan
    Rhyl
    LL18 5UJ
  • Western General Hospital
    Crewe Road South Edinburgh
    Lothian
    EH4 2XU
  • Forth Valley Royal Hospital
    Stirling Road
    Larbert
    FK5 4WR
  • Royal Liverpool University Hospital
    Prescot Street
    Liverpool
    L7 8XP
  • Royal Bournemouth General Hospital
    Castle Lane East
    Bournemouth
    BH7 7DW
  • East Surrey Hospital
    Canada Avenue
    Redhill
    RH1 5RH
  • Princess Alexandra Hospital
    Hamstel Road
    Harlow
    CM20 1QX
  • Leighton Hospital
    Leighton
    Crewe
    CW1 4QJ
  • Milton Keynes University Hospital
    Standing Way Eaglestone
    Milton Keynes
    MK6 5LD
  • Stoke Mandeville Hospital
    Mandeville Road
    Aylesbury
    HP21 8AL
  • Singleton Hospital
    Sketty Lane Sketty
    Swansea
    SA2 8QA
  • Darlington Memorial Hospital
    Hollyhurst Road
    Darlington
    DL3 6HX
  • Poole Hospital
    Longfleet Road
    Poole
    BH15 2JB
  • Pilgrim Hospital
    Sibsey Road
    Boston
    PE21 9QS
  • Wythenshawe Hospital
    Southmoor Road Wythenshawe
    Manchester
    M23 9LT
  • Lincoln County Hospital
    Greetwell Road
    Lincoln
    LN2 5QY
  • University Hospital of North Tees
    Hardwick Road
    Stockton-on-tees
    TS19 8PE
  • George Eliot Hospital
    Lewes House College Street
    Nuneaton
    CV10 7DJ
  • The Whittington Hospital
    Highgate Hill
    London
    N19 5NF
  • Wrexham Maelor Hospital
    Croesnewydd Road Wrexham Technology Park
    Wrexham
    LL13 7TD
  • Royal Albert Edward Infirmary
    Wigan Lane
    Wigan
    WN1 2NN
  • St Albans City Hospital
    Waverley Road St Albans
    St. Albans
    AL3 5PN
  • Airedale General
    Airedale General Hospital Skipton Road, Steeton
    Keighley
    BD20 6TD
  • St Mary's Hospital
    St. Marys Hospital West Wing Milton Road
    Portsmouth
    PO3 6AD
  • Basingstoke and North Hants Hospital
    Aldermaston Road
    Basingstoke
    RG24 9NA
  • Royal Hampshire County Hospital
    Romsey Road
    Winchester
    SO22 5DG
  • Bronglais General Hospital
    Bronglais Hospital Caradoc Road
    Aberystwyth
    SY23 1ER
  • University Hospitals Coventry & Warwickshire
    Clifford Bridge Road
    Coventry
    CV2 2DX
  • St John's Hospital
    Howden West Livingston
    Lothian
    EH54 6PP
  • Conquest Hospital
    The Ridge
    St. Leonards-on-sea
    TN37 7RD
  • Tameside General Hospital
    Fountain Street
    Ashton-under-lyne
    OL6 9RW
  • West Suffolk Hospital
    Hardwick Ln
    Bury Saint Edmunds
    IP33 2QZ

It is not known whether the HT&Me support package will be effective in helping women to continue taking their hormone therapy as prescribed or in improving quality-of-life, however, women in Group A who receive the intervention will receive more information and support whilst taking their hormone therapy and they may find this helpful. Participants may not directly benefit from taking part in this research, but your participation will help guide support for women with breast cancer taking hormone therapy in the future. There are no physical risks involved in taking part in the study, although being asked questions about cancer may be upsetting

Prof Linda Sharp
+44 (0)1912086275
SWEET@warwick.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by Newcastle upon Tyne Hospitals NHS Foundation Trust and funded by NIHR Central Commissioning Facility (CCF); Grant Codes: NIHR200098.




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Read full details for Trial ID: ISRCTN24852890

Or CPMS 57385

Last updated 11 February 2025

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