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Be Part of Research - Trial Details - A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Neoplasms
Carcinoma, Non-Small-Cell Lung
Head and Neck Neoplasms
Ovarian Neoplasms
Endometrial Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This clinical trial is studying advanced or metastatic solid tumors. Once a solid tumor has grown very large in one spot or has spread to other places in the body, it is called advanced or metastatic cancer. Participants in this study must have head and neck cancer, non-small cell lung cancer, endometrial cancer, or ovarian cancer. In the first part of the study, participants must have tumors that have a marker called HER2.

This clinical trial uses an experimental drug called disitamab vedotin (DV). DV is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. In this study, all participants will get DV once every 2 weeks.

This study is being done to see if DV works to treat different types of solid tumors that express HER2. It will also test how safe the drug is for participants. This trial will also study what side effects happen when participants get the drug. A side effect is anything a drug does to your body besides treating the disease.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 May 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Given into the vein (IV, intravenous) every 2 weeks

Intervention Arm Group : Endometrial cancer;Head and neck cancer;Non-small cell lung cancer;Ovarian cancer;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Royal Marsden NHS Foundation Trust (RM)
    Sutton
    Surrey
    SM2 5PT
  • University College London Hospitals NHS Foundation Trust
    London
    NW1 2PG
  • The Royal Marsden NHS Foundation Trust (RM)
    London
    SW3 6JJ
  • University College London Hospitals NHS Foundation Trust
    London
    W17 7HA


The study is sponsored by Seagen, a wholly owned subsidiary of Pfizer




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Read full details for Trial ID: NCT06003231
Last updated 02 April 2025

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