Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Miss Jeannie McKie
j.mckie@nhs.net


Dr Jaime Delgadillo
j.delgadillo@sheffield.ac.uk


Jeannie McKie
rdash.research-gov@nhs.net


Uplift-X Trial Team
rdash.upliftx@nhs.net


Study Location:

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Be Part of Research - Trial Details - UPLift-X Trial

UPLift-X Trial

Recruiting

Open to: Female / Male

Age: 17 Years - N/A

Medical Conditions

Mood [affective] disorders
Neurotic, stress-related and somatoform disorders


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Mental health problems are common and affect around one in six adults. Most countries lack sufficient mental health provision to meet the needs of people with common mental disorders (CMD). Four developments in the psychotherapy field have the potential to address the shortfalls in access and effectiveness of treatment; 1) efficient group-based psychological therapy, 2) effective ‘transdiagnostic’ interventions relevant for a wide variety of CMDs, 3) accessible internet-delivered digital psychological interventions and 4) personalised treatment tailored for each patient. UpLift-X is a research programme than aims to integrate all these four advances into a single and comprehensive digital health platform, which we expect will be a cost-effective solution to maximize access to highly effective treatment for a large population of patients with CMDs. The overall aim of this study is to test the effectiveness of a modularised, transdiagnostic, digitally-enabled 12-session group intervention for the treatment of CMD, based on the Unified Protocol (UP) for the treatment of emotional disorders. The therapy will be accessed on a digital platform which will include helpful videos and information about coping skills. Funded by Innovate UK, a pragmatic, multi-site, factorial cluster randomised controlled trial will recruit patients accessing NHS Talking Therapies treatment for CMDs. The trial will evaluate if altering the sequence of UP therapy modules affects clinical outcomes or drop-out and aim to develop a personalised module selection method to tailor treatment to the needs of patients with a wide range of clinical problems. The study will also evaluate the clinical and cost-effectiveness of digitally-enabled group therapy compared to individual Cognitive Behavioural Therapy (current standard treatment).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

30 Apr 2025 20 Oct 2026

Interventional

Interventional type: Psychological & Behavioural;



You can take part if:



You may not be able to take part if:


Age < = 16. Not able to speak or read English fluently, which would require more individualised support with interpreters. No access to internet-connected device or confidential space to engage with digital intervention. Not involved with NHS-Talking Therapies services. Assessed by a qualified psychological professional and not deemed to be eligible for high intensity Cognitive Behavioural Therapy( CBT) on the basis of mental health condition and/or risk assessment (e.g., acute risk of suicide at the time of assessment). Already accessing a high intensity psychotherapy or other forms of psychological treatment (e.g., private therapy, counselling) Presenting with symptoms of eating disorders, substance use disorders, psychotic disorders, personality disorders, bipolar disorders identified at the time of initial assessment.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Lantern Centre
    Vicarage Lane
    fulwood
    Preston
    Lancashire
    PR2 8DW
  • Trust Headquarters
    9 Alie Street
    aldgate
    London
    Greater London
    E1 8DE
  • Wonford House
    Wonford House Hospital
    dryden Road
    Exeter
    Devon
    EX2 5AF
  • Pennine Care NHS Trust
    225 Old Street
    Ashton-under-lyne
    Lancashire
    OL6 7SR
  • Central & North West London NHS Foundation Trust Headquarters
    Greater London House
    hampstead Road
    London
    Greater London
    NW1 7QY
  • Armstrong Way Mh
    1 Armstrong Way
    Southall
    Middlesex
    UB2 4SA
  • Doncaster Iapt
    Talking Shop
    63 Hall Gate
    Doncaster
    South Yorkshire
    DN1 3PB

Jeannie McKie
rdash.research-gov@nhs.net


Dr Jaime Delgadillo
j.delgadillo@sheffield.ac.uk


Uplift-X Trial Team
rdash.upliftx@nhs.net


Miss Jeannie McKie
j.mckie@nhs.net



The study is sponsored by ROTHERHAM DONCASTER AND SOUTH HUMBER NHS FOUNDATION TRUST and funded by Innovate UK .




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for Trial ID: CPMS 63638

Last updated 30 March 2026

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