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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Other diseases of blood and blood-forming organs
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The immune system is a complex series of cells and molecules that interacts with every tissue and system in the body, including the endothelial cells that line blood vessels. When the body is exposed to infection or trauma, inflammation can start to damage the body. When immune cells damage endothelial cells, changes happen to the instructional molecules (mRNA) which alter function. This change in function allows fluid from your blood can leak into the surrounding tissues, blood pressure drops and blood clotting. This leads to organ damage and death. This study aims to capture endothelial cells from patients exposed to trauma (surgery) or infection (sepsis) with the intention to study the change in mRNA.
During a previous study, our research team tested the feasibility of using a technique known as endovascular biopsy to safely isolate these cells from patients. The procedure involves inserting a cannula into a forearm vein of a patient, then gently passing a small guidewire into the vessel to isolate endothelial cells. These cells are then isolated in a laboratory. For this study we plan to use this technique again to isolate endothelial cells while taking a blood sample at the same time.
All participants involved in this study will be a patient at Royal Surrey Hospital. They will either be undergoing major abdominal surgery and requiring recovery in Intensive Care or admitted to Intensive Care due to severe illness. Patient involvement in the study will last 3 days post enrolment and will not affect any other aspects of their care.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
Healthy volunteer • Not currently a patient within the hospital • Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD. • Not on immunomodulatory medications, such as corticosteroids • History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation) Surgical patients • Inadequate English language proficiency • Prisoners • Anticipated prohibitively difficult venous cannulation • Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, sepsis, diabetes with end organ damage, cardiovascular disease and CKD • Currently prescribed immunomodulatory medication or immunocompromised • Received chemotherapy within 2 weeks of predicted sampling • Receiving vasopressor support prior to surgery • History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation) Critically ill patients • Inadequate English language proficiency • Prisoners • Anticipated prohibitively difficult venous cannulation • Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes with end organ damage, cardiovascular disease and CKD. • Currently prescribed immunomodulatory medication or immunocompromised • Received chemotherapy within 2 weeks of predicted sampling. • History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by ROYAL SURREY COUNTY HOSPITAL NHS FOUNDATION TRUST and funded by European Society of Intensive Care Medicine; University of Surrey; GUTS; .
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Read full details
for Trial ID: CPMS 61240
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