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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Mrs Allison Jones
+44 (0)203 108 2003
allison.jones@ucl.ac.uk


Dr Dan Reisel
+44 (0)203 108 2003
d.reisel@ucl.ac.uk


Prof Martin Widschwendter
+44 (0)203 108 2003
m.widschwendter@ucl.ac.uk


Dr Ojone Illah
+44 (0)203 108 2003
o.illah@ucl.ac.uk


Dr Iona Evans
+44 (0)203 108 2003
iona.evans@ucl.ac.uk


Study Location:

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Be Part of Research - Trial Details - Comparing molecular and imaging techniques for the detection of womb cancer in black women
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Comparing molecular and imaging techniques for the detection of womb cancer in black women

Recruiting

Open to: Female

Age: Adult

Croydon London London

Medical Conditions

Endometrial cancer

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study aims to improve the diagnosis of womb (endometrial) cancer amongst black women in the UK. This is the fourth most common cancer in the UK and black women are more likely to be diagnosed at an advanced stage of disease. This worsens their outcomes.
There is currently no screening programme for womb cancer. Most women will present symptomatically with abnormal vaginal bleeding which is considered a red flag. Only a small number of these women will have womb cancer, but clinical assessment is focused on correctly identifying these women for prompt diagnosis and treatment.
In the UK, the gold standard for assessing these women is using transvaginal ultrasound. This approach can sometimes be inaccurate and result in either missed diagnoses, or the need for multiple invasive confirmatory diagnostic tests, in order to detect each case of womb cancer.
The novel WID™-qEC test is a molecular test based on cervical and vaginal swab specimens. It has been shown to be highly sensitive and specific for diagnosing womb cancer, but not adequately studied in black women.
The aim of this study is to assess the performance of the WID™-qEC test in detecting womb cancer in black women. This will be compared with ultrasound triage and the diagnostic accuracy of the two approaches will be compared.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

23 Jan 2024 31 Jul 2025

Each participant will require two swabs. One is a self-collected swab from the lower vagina. Instructions for how to collect this will be given to participants. The second is a high vaginal swab from behind the cervix, visualised when the participant undergoes a speculum examination as part of their clinical assessment. Samples will be labelled with an anonymised barcode sticker.


Women aged 50 years or above who present to rapid access Gynaecology clinics with abnormal vaginal bleeding warranting further investigation. Women should self-identify as belonging to one of the following ethnic groups:
1. Black, African, or Caribbean
2. Mixed/multiple ethnic groups (Black African or Caribbean and other ethnic background)

What does the study involve?
Each participant will require two swabs. One is a self-collected swab from the lower vagina. Instructions for how to collect this will be given to participants. The second is a high vaginal swab from behind the cervix, visualised when the participant undergoes a speculum examination as part of their clinical assessment. Samples will be labelled with an anonymised barcode sticker.

You can take part if:



You may not be able to take part if:


1. Current hormone replacement therapy (HRT) use2. History of hysterectomy


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Croydon University Hospital
    London Road
    Croydon
    CR7 7YE
  • Guys Hospital
    Guys Hospital Great Maze Pond
    London
    SE1 9RT
  • Golden Jubilee Wing Suite 3, King's College Hospital
    Golden Jubilee Wing Suite 3 Kings College Hospital Denmark Hill
    London
    SE5 9RS

This study is altruistic, there is no remuneration to take part. Risks include a small amount of bleeding and discomfort from the cervical brush sample. Participants will not personally benefit from taking part in the study.

Dr Ojone Illah
+44 (0)203 108 2003
o.illah@ucl.ac.uk


Dr Dan Reisel
+44 (0)203 108 2003
d.reisel@ucl.ac.uk


Mrs Allison Jones
+44 (0)203 108 2003
allison.jones@ucl.ac.uk


Dr Iona Evans
+44 (0)203 108 2003
iona.evans@ucl.ac.uk


Prof Martin Widschwendter
+44 (0)203 108 2003
m.widschwendter@ucl.ac.uk



The study is sponsored by University College London and funded by The Eve Appeal ; Universität Innsbruck.



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What will you do next?
Read full details for Trial ID: ISRCTN12265297

Or CPMS 30876

Last updated 27 March 2025

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