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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or 13176154559
clinical_inquiry_hub@lilly.com


Study Location:

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Be Part of Research - Trial Details - FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Urinary Bladder Neoplasms
Neoplasm Metastasis
Ureteral Neoplasms
Urologic Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a particular gene (known as the FGFR3 gene). Participation could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2023 Jun 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral

Intervention Arm Group : Phase 1a: Cohort A1 LOXO-435 Monotherapy Dose Escalation;Phase 1a: Cohort A2 LOXO-435 Monotherapy Dose Optimization;Phase 1b: Cohort B1, B2, B4, and C1 LOXO-435 Monotherapy Dose Expansion;Phase 1b: Cohort B3 LOXO-435 Plus Pembrolizumab;Phase 1b: Cohort B5 LOXO-435 Plus Pembrolizumab Plus Enfortumab Vedotin;

Intervention Type : DRUG
Intervention Description : IV

Intervention Arm Group : Phase 1b: Cohort B3 LOXO-435 Plus Pembrolizumab;Phase 1b: Cohort B5 LOXO-435 Plus Pembrolizumab Plus Enfortumab Vedotin;

Intervention Type : DRUG
Intervention Description : IV

Intervention Arm Group : Phase 1b: Cohort B5 LOXO-435 Plus Pembrolizumab Plus Enfortumab Vedotin;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Sheffield Teaching Hospitals NHS Foundation Trust
    Sheffield
    S10 2SB
  • The Christie NHS Foundation Trust
    Manchester
    M20 4BX

There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or 13176154559
clinical_inquiry_hub@lilly.com



The study is sponsored by Eli Lilly and Company




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Read full details for Trial ID: NCT05614739
Last updated 22 August 2025

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