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Be Part of Research - Trial Details - A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to assess the feasibility of subcutaneous (SC) administration of amivantamab based on safety and pharmacokinetics and determine a dose, dose regimen and formulation for amivantamab SC delivery.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2020 Jul 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Participants will receive amivantamab admixed with rHuPH20 SC infusion.

Intervention Arm Group : Part 1: Ami-LC-MD and Ami-LC;

Intervention Type : DRUG
Intervention Description : Participants will receive amivantamab SC infusion.

Intervention Arm Group : Part 1: Ami-LC-MD and Ami-LC;

Intervention Type : DRUG
Intervention Description : Participants will receive amivantamab SC infusion.

Intervention Arm Group : Part 2: Ami-HC and Ami-HC-CF;Part 3: Ami-HC-CF + Lazertinib and Ami-HC+ Lazertinib;

Intervention Type : DRUG
Intervention Description : Participants will receive amivantamab co-formulated with rHuPH20 as SC infusion.

Intervention Arm Group : Part 2: Ami-HC and Ami-HC-CF;Part 3: Ami-HC-CF + Lazertinib and Ami-HC+ Lazertinib;

Intervention Type : DRUG
Intervention Description : Participants will receive lazertinib orally as a film-coated tablet.

Intervention Arm Group : Part 3: Ami-HC-CF + Lazertinib and Ami-HC+ Lazertinib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Marsden Hospital
    Sutton
    SM2 5PT
  • The Christie Nhs Foundation Trust
    Manchester
    M20 4BX


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT04606381
Last updated 29 March 2025

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