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Glomerular diseasesRenal failureOedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
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Chronic kidney disease (CKD) affects 3% of women of childbearing age. These women have a greater risk of maternal and fetal complications than almost any other chronic disease. Their risk of developing a condition called pre-eclampsia is increased. Pre-eclampsia is potentially life-threatening for both mother and baby. The only cure is to deliver the baby. Pre-eclampsia is diagnosed by detecting an increase in blood pressure and protein in the urine during pregnancy. This diagnosis is difficult in chronic kidney disease as high blood pressure and protein in the urine can result from kidney disease, in the absence of pre-eclampsia. It can be difficult to know whether or not to deliver babies if you cannot be sure whether the mother has pre-eclampsia or not. In addition, both pre-eclampsia
and the physiological changes of pregnancy can affect renal function This makes the diagnosis of kidney injury in pregnancy difficult.
This study is looking for a better diagnostic test for both pre-eclampsia and kidney injury in pregnancy in women with chronic kidney disease.
This study will examine blood and urine samples from women with chronic kidney disease at different stages of their pregnancy. It will examine markers of placental function, kidney injury and mediators of renal physiological change in pregnancy. This data will be compared to both women without CKD in pregnancy and to women with CKD who are not pregnant.
Data from this study will lead to increased understanding of the pathological mechanisms by which CKD impacts pregnancy. The aim is to develop predictors of maternal and neonatal outcome which can guide antenatal care, treatment and delivery. It will also facilitate the assessment of established therapy, and identify pathways for novel
therapeutic intervention.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
None
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by King's College London and funded by NIHR Rare Diseases Translational Research Collaboration .
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Read full details
for Trial ID: CPMS 18288
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