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Contact Information:

Dr Najib Rahman


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Be Part of Research - Trial Details - The second multi-centre intra-pleural sepsis trial (MIST2), to assess whether DNase or Alteplase, improve pleural fluid drainage in pleural infection
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The second multi-centre intra-pleural sepsis trial (MIST2), to assess whether DNase or Alteplase, improve pleural fluid drainage in pleural infection

Not Recruiting

Open to: All Genders

Age: Not Specified

Oxford

Medical Conditions

Pleural infection

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

11 Oct 2003 11 Oct 2007

Publications

2011 Results article in http://www.ncbi.nlm.nih.gov/pubmed/21830966 results

Interventional

Intervention Type : Other
Intervention Description : Patients will be randomly assigned in the ratio 1:1:1:1 to either of the following regimes:Alteplase 10 mg bd (twice a day) intrapleurally + DNase 5 mg bd intrapleurallly; orAlteplase placebo intrapleurally + DNase 5 mg bd intrapleurally; orAlteplase 10 mg bd intrapleurally + DNase placebo intrapleurally; orAlteplase placebo intrapleurally + DNase placebo intrapleurally.




You can take part if:



You may not be able to take part if:


1. Age <18 years2. Has previously received intra-pleural fibrinolytics or DNase for this empyema3. Has a known sensitivity to DNase or tissue plasminogen activator4. Has had a coincidental stroke, a major haemorrhage or major trauma5. Has had major surgery in the previous 5 days6. Has had a previous pneumonectomy on the side of infectionPatients who are pregnant or lactating (females of childbearing potential must have a negative pregnancy test before randomisation)Expected survival less than three months from a different pathology to this empyema (e.g. metastatic lung carcinoma)Inability to give informed consent


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Academic Clinical Lecturer
    Oxford
    OX3 7LJ

This information has not yet been provided by the study team. You'll have an opportunity to discuss any risks and benefits that may be associated with this study prior to consenting to taking part.

Dr Najib Rahman



The study is sponsored by Oxford Radcliffe Hospitals NHS Trust (UK) and funded by Unrestricted educational grant from Roche UK.



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Read full details for Trial ID: ISRCTN57454527
Last updated 15 August 2011

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