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Contact Information:

Ms Rachael Gilberts
+44 113 343 0254
R.M.Gilberts@leeds.ac.uk


Study Location:

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Be Part of Research - Trial Details - UK GRACE Risk Score Intervention Study

UK GRACE Risk Score Intervention Study

Medical Conditions

Acute coronary syndrome (ACS)


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Acute coronary syndrome (ACS) refers to a group of conditions due to decreased blood flow in the coronary arteries such that part of the heart muscle is unable to function properly or dies. It encompasses a range of sudden heart conditions, including heart attack and unstable angina attack (sudden chest pain). ACS mainly happens due to narrowing of the blood vessels which supply the heart due to a build-up of plaque (a fatty, sticky substance) on the walls of arteries. The GRACE risk score tool is a special tool which can be used by healthcare professionals (such as doctors) to calculate the risks of further heart attack or death after acute coronary syndrome (type of unstable angina attack or heart attack), by looking at medical information that is routinely collected during hospital stays. The aim of this study is to find out whether there is a difference in patient’s health status following an unstable angina attack or a heart attack if treated according to usual care or if treated using the GRACE risk score tool.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

23 Jan 2017 31 Dec 2019

Publications

2019 Protocol article in https://bmjopen.bmj.com/content/9/9/e032165.info (added 12/08/2022)2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37315959/ (added 15/06/2023)

Participating hospitals are randomly allocated to one of two groups. Hospitals in the first group use the GRACE risk score tool within routine clinical assessment and management procedures. This involves individual participants who agree to take part having their GRACE risk score calculated and used to help decide their treatment. Hosptials in the second group continue to follow their current practice. In both groups, participants complete a general health assessment and a short questionnaire at the start of the study and then again 12 months later to assess their health status. Participants’ long-term progress relating to their heart condition is also assessed by reviewing electronic medical records.


Adults who have been admitted to hospital with a suspected acute coronary syndrome.

You can take part if:



You may not be able to take part if:


Research sites exclusion criteria:GRACE risk tool already implemented.

Patient exclusion criteria:1. Patients presenting at hospital due to an acute ST-segment elevation myocardial infarction (STEMI)2. Patients presenting at hospital with an ACS accompanied with, or precipitate by significant co-morbidity e.g. motor vehicle accident, trauma, severe gastrointestinal bleeding3. Peri-operative or peri-procedural MI4. Patients already recruited into the study


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Blackburn Hospital
    Haslingden Road
    Blackburn
    BB2 3HH
  • Yeovil District Hospital
    Higher Kingston
    Yeovil
    BA21 4AT
  • Leighton Hospital
    Middlewich Road
    Crewe
    CW1 4QJ
  • East Surrey Hospital
    Canada Avenue
    Redhill
    RH1 5RH
  • Blackpool Victoria Hospital
    Whinney Heys Road
    Blackpool
    FY3 8NR
  • Royal Lancaster Infirmary
    Ashton Road
    Lancaster
    LA1 4RP
  • Furness General Hospital
    Dalton Lane
    Barrow-in-furness
    LA14 4LF
  • Royal Chesterfield Hospital
    Top Road Calow
    Chesterfield
    S44 5BL
  • York Hospital
    Wiggington Road
    York
    YO31 8HE
  • Conquest Hospital
    The Ridge
    St Leonards On Sea
    TN37 7RD
  • Royal Sussex County Hospital
    Sussex Cancer Centre Eastern Road
    Brighton
    BN2 5BE
  • Torbay District General Hospital
    Heart and Lung Unit Lowes Bridge
    Torquay
    TQ2 7AA
  • West Middlesex University Hospital
    Chelsea & Westminster Hospital NHS Foundation Trust Twickenham Road
    Isleworth
    TW7 6AF

There are no guaranteed benefits of participating, however the information gained from this study could help improve the treatment of people with ACS in the future. There are no notable risks involved with participating.


The study is sponsored by University of Leeds and funded by British Heart Foundation.




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Read full details for Trial ID: ISRCTN29731761

Or CPMS 32356

Last updated 15 June 2023

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